The biochemically analyze Notch1 mutations linked to Adams-Oliver syndrome
| Project/Area Number |
15K18502
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Research Collaborator |
SAWAGUCHI SHOGO 名古屋大学, 大学院医学系研究科, 大学院生
Didarul Alam Sayed M.d 名古屋大学, 大学院医学系研究科, 大学院生
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | NOTCH / アダムズ-オリバー症候群 / Notch1 / Notchシグナル / 分子機能異常 / Notch / O-GlcNAc / 先天性疾患 |
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| Outline of Final Research Achievements |
The mutations of NOTCH1 are found in the Adams-Oliver syndrome (AOS) patients. The aim of this study is to biochemically analyze Notch1 mutations linked to AOS and demonstrate that Notch1 mutations found in AOS is shown as the dysfunction of Dll4-Notch binding. Those results suggest that impaired Dll4-Notch1 signaling may be an alternative basis of the pathogenesis of AOS.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Ganglioside GD3 enhances invasiveness via Yes activation by forming a complex of GD3/PDGFRα/Yes in gliomas2015
Author(s)
Yuki Ohkawa, Hiroyuki Momota, Akira Kato, Noboru Hashimoto, Yuhsuke Tsuda, Norihiro Kotani, Koichi Honke, Akio Suzumura, Keiko Furukawa, Yuhsuke Ohmi, Atsushi Natsume, Toshihiko Wakabayashi and *Furukawa K
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Journal Title
J. Biol. Chem.
Volume: 290
Issue: 32
Pages: 16043-16058
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Extracellular O-GlcNAc is required for retinal vascular development and Dll4-Notch signaling.2016
Author(s)
Mitsutaka Ogawa, Shweta Varshney, Shogo Sawaguchi, Yuta Sakaidani, Hirokazu Yagi, Kyosuke Takeshita, Toyoaki Murohara, Koichi Kato, Pamela Stanley, Tetsuya Okajima.
Organizer
Society for Glycobiology 2016 ANNUAL MEETING
Place of Presentation
アメリカ, ニューオリンズ
Year and Date
2016-11-19
Related Report
Int'l Joint Research
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[Presentation] 脳血管における細胞外 O-GlcNAc 修飾の生物学的意義2015
Author(s)
Mitsutaka Ogawa, Shogo Sawaguchi, Pawel Bieniasz-Krzywiec, Hirokazu Yagi, Koichi Kato, Jiro Usukura, Koichi Furukawa, Tetsuya Okajima
Organizer
平成27年度神経糖鎖生物学 夏の班会議
Place of Presentation
とりぎん文化会館（鳥取県鳥取市）
Year and Date
2015-06-25
Related Report
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