| Project/Area Number |
15K18502
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Research Collaborator |
SAWAGUCHI SHOGO 名古屋大学, 大学院医学系研究科, 大学院生
Didarul Alam Sayed M.d 名古屋大学, 大学院医学系研究科, 大学院生
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | NOTCH / アダムズ-オリバー症候群 / Notch1 / Notchシグナル / 分子機能異常 / Notch / O-GlcNAc / 先天性疾患 |
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| Outline of Final Research Achievements |
The mutations of NOTCH1 are found in the Adams-Oliver syndrome (AOS) patients. The aim of this study is to biochemically analyze Notch1 mutations linked to AOS and demonstrate that Notch1 mutations found in AOS is shown as the dysfunction of Dll4-Notch binding. Those results suggest that impaired Dll4-Notch1 signaling may be an alternative basis of the pathogenesis of AOS.
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