Sturcture-function relationship of a high-order replication initiator complex in DNA recognition and functional switching
| Project/Area Number |
15K18504
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 染色体複製 / ORC / 機能構造解析 / DNA結合 / 制御因子 |
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| Outline of Final Research Achievements |
The origin recognition complex, an initiator of eukaryotic DNA replication, was extensively analyzed in vitro and in vivo. Certain structure-function relationships were identified and a novel multifaceted DNA recognition mechanism was proposed.
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Report
(3 results)
Research Products
(36 results)
