Analysis of alternation for RNA granules-ncRNA function via mitochondrial dynamics
| Project/Area Number |
15K18508
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional biochemistry
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| Research Institution | Kurume University |
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Principal Investigator |
Ishihara Takaya 久留米大学, 分子生命科学研究所, 助教 (70611862)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ミトコンドリアダイナミクス / mtDNA / ミトコンドリア / シグナル伝達 |
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| Outline of Final Research Achievements |
In this study, I aimed to reveal the role of morphological changes of mitochondria in maintenance for physiological functions. From our recent research, we found that mitochondrial membranes and mitochondrial DNA (mtDNA) worked in part cooperatively. Therefore, in order to clarify the mechanistic insight between mitochondrial membrane and mtDNA dynamics, I performed several screening. Some factors could be identified in this screening, and the regulator of cellular function through the change of dynamics of mitochondrial membrane and mtDNA might be revealed at the molecular level.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration.2015
Author(s)
Wang L, Ishihara T, Ibayashi Y, Tatsushima K, Setoyama D, Hanada Y, Takeichi Y, Sakamoto S, Yokota S, Mihara K, Kang D, Ishihara N, Takayanagi R, Nomura M
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Journal Title
Diabetologia
Volume: 58
Issue: 10
Pages: 2371-2380
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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