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Analysis of alternation for RNA granules-ncRNA function via mitochondrial dynamics

Research Project

Project/Area Number 15K18508
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional biochemistry
Research InstitutionKurume University

Principal Investigator

Ishihara Takaya  久留米大学, 分子生命科学研究所, 助教 (70611862)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsミトコンドリアダイナミクス / mtDNA / ミトコンドリア / シグナル伝達
Outline of Final Research Achievements

In this study, I aimed to reveal the role of morphological changes of mitochondria in maintenance for physiological functions. From our recent research, we found that mitochondrial membranes and mitochondrial DNA (mtDNA) worked in part cooperatively. Therefore, in order to clarify the mechanistic insight between mitochondrial membrane and mtDNA dynamics, I performed several screening. Some factors could be identified in this screening, and the regulator of cellular function through the change of dynamics of mitochondrial membrane and mtDNA might be revealed at the molecular level.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Invited: 1 results)

  • [Journal Article] Aclarubicin, an anthracycline anti-cancer drug, fluorescently contrasts mitochondria and reduces the oxygen consumption rate in living human cells2017

    • Author(s)
      Iihoshi Haruka、Ishihara Takaya、Kuroda Shogo、Ishihara Naotada、Saitoh Hisato
    • Journal Title

      Toxicology Letters

      Volume: 277 Pages: 109-114

    • DOI

      10.1016/j.toxlet.2017.06.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin.2017

    • Author(s)
      Ban T, Ishihara T, Kohno H, Saita S, Ichimura A, Maenaka K, Oka T, Mihara K, Ishihara N.
    • Journal Title

      Nat Cell Biol.

      Volume: 19(7) Issue: 7 Pages: 856-863

    • DOI

      10.1038/ncb3560

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distinct types of protease systems are involved in homeostasis regulation of mitochondrial morphology via balanced fusion and fission.2016

    • Author(s)
      Saita S, Ishihara T, Maeda M, Iemura S, Natsume T, Mihara K, Ishihara N.
    • Journal Title

      Genes Cells

      Volume: 21(5) Issue: 5 Pages: 408-424

    • DOI

      10.1111/gtc.12351

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration.2015

    • Author(s)
      Wang L, Ishihara T, Ibayashi Y, Tatsushima K, Setoyama D, Hanada Y, Takeichi Y, Sakamoto S, Yokota S, Mihara K, Kang D, Ishihara N, Takayanagi R, Nomura M
    • Journal Title

      Diabetologia

      Volume: 58 Issue: 10 Pages: 2371-2380

    • DOI

      10.1007/s00125-015-3704-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Physiological roles of mitochondrial fission in cultured cells and mouse development.2015

    • Author(s)
      Ishihara T, Kohno H, Ishihara N.
    • Journal Title

      Ann N Y Acad Sci.

      Volume: 1350 Issue: 1 Pages: 77-81

    • DOI

      10.1111/nyas.12848

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] ミトコンドリアの膜とmtDNAのダイナミクスを制御する因子の探索2017

    • Author(s)
      石原孝也、石原直忠
    • Organizer
      ConBio2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] ミトコンドリアの膜とmtDNAのダイナミクスを制御する因子の解析2017

    • Author(s)
      石原孝也、石原直忠
    • Organizer
      平成29年度日本生化学会九州支部例会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ミトコンドリアの膜と mtDNA のダイナミクスを制御する因子の探索2016

    • Author(s)
      石原孝也 石原直忠
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] 成長期の骨格筋におけるDrp1の機能2016

    • Author(s)
      一村 紋佳、石原 孝也、石原 直忠
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] ミトコンドリアの膜とゲノムの協調的な形態制御2016

    • Author(s)
      伴 匡人、石原 孝也、太田 あずさ、石原 直忠
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] ミトコンドリアの膜とDNAの協調的かつ動的な制御機構2015

    • Author(s)
      石原 孝也, 石原 直忠
    • Organizer
      BMB2015
    • Place of Presentation
      神戸ボートピアホテル(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 哺乳動物におけるミトコンドリアの膜とDNAのダイナミクス2015

    • Author(s)
      石原孝也
    • Organizer
      YoungMito2015
    • Place of Presentation
      シーサイド一宮オーツカ(千葉県長生郡)
    • Year and Date
      2015-07-10
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-12-27  

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