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Analysis of molecular mechanism of cell protective function of Derlin-3

Research Project

Project/Area Number 15K18510
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional biochemistry
Research InstitutionNational Cardiovascular Center Research Institute

Principal Investigator

Eura Yuka  国立研究開発法人国立循環器病研究センター, 研究所, 研究員 (30443477)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsERAD / ER stress / Derlin-3 / Herp / 小胞体関連分解 / 小胞体ストレス / Derlin
Outline of Final Research Achievements

ER-associated degradation (ERAD) contributes to the maintenance of cellular homeostasis by degrading and eliminating structurally abnormal proteins generated in the endoplasmic reticulum. In this study, we focused on Derlin-3 whose expression is induced by endoplasmic reticulum stress and analyzed the importance of its function. In the in vivo experiments using hypoxic conditions, we found that Derlin-3 deficient mice exhibited the survival vulnerability. Herp (a protein forming an ERAD complex with Derlin-3)-deficient mice also exhibited the vulnerability. We also found that these mice have functional abnormalities in their hearts. Our findings that Herp controls the level of IP3 receptor, an intracellular signal transduction protein in the heart, may partly explain the cardiac abnormalities of Derlin-3 and Herp deficient mice.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (14 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (1 results)

  • [Int'l Joint Research] チリ大学(チリ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] チリ大学(チリ)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] チリ大学(チリ)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis2018

    • Author(s)
      Navarro-Marquez Mario、Torrealba Natalia、Troncoso Rodrigo、V?squez-Trincado Cesar、Rodriguez Marcelo、Morales Pablo E.、Villalobos Elisa、Eura Yuka、Garcia Lorena、Chiong Mario、Klip Amira、Jaimovich Enrique、Kokame Koichi、Lavandero Sergio
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

      Volume: 1864 Issue: 5 Pages: 1653-1662

    • DOI

      10.1016/j.bbadis.2018.02.018

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Revised mechanisms of thrombus formation and next-generation anti-thrombotic strategy2017

    • Author(s)
      Toshiyuki Miyata, Yuka Eura, Mitsuhiko Sugimoto
    • Journal Title

      生化学

      Volume: 89 Issue: 3 Pages: 333-342

    • DOI

      10.14952/SEIKAGAKU.2017.890333

    • ISSN
      0037-1017
    • Year and Date
      2017-06-25
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation2017

    • Author(s)
      Torrealba Natalia、Navarro-Marquez Mario、Garrido Valeria、Pedrozo Zully、Romero Diego、Eura Yuka、Villalobos Elisa、Roa Juan Carlos、Chiong Mario、Kokame Koichi、Lavandero Sergio
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 13402-13402

    • DOI

      10.1038/s41598-017-13797-z

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Candidate gene analysis using genomic quantitative PCR: Identification of <i>ADAMTS13</i> large deletions in two patients with Upshaw-Schulman syndrome2017

    • Author(s)
      Yuka Eura
    • Journal Title

      Japanese Journal of Thrombosis and Hemostasis

      Volume: 28 Issue: 4 Pages: 537-542

    • DOI

      10.2491/jjsth.28.537

    • NAID

      130005966818

    • ISSN
      0915-7441, 1880-8808
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of a rotational speed modulation system used with an implantable continuous-flow left ventricular assist device (EVAHEART) on von Willebrand factor dynamics2016

    • Author(s)
      Noritsugu Naito, Toshihide Mizuno, Takashi Nishimura, Satoru Kishimoto, Yoshiaki Takewa, Yuka Eura, Koichi Kokame, Toshiyuki Miyata, Kazuma Date, Akihide Umeki, Masahiko Ando, Minoru Ono, and Eisuke Tatsumi
    • Journal Title

      Artif. Organs

      Volume: 未定 Issue: 9 Pages: 877-883

    • DOI

      10.1111/aor.12666

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency.2016

    • Author(s)
      Fan X, Kremer Hovinga JA, Shirotani-Ikejima H, Eura Y, Hirai H, Honda S, Kokame K, Taleghani MM, von Krogh AS, Yoshida Y, Fujimura Y, Lammle B, Miyata T
    • Journal Title

      Int J Hematol

      Volume: 103 Issue: 3 Pages: 283-291

    • DOI

      10.1007/s12185-015-1933-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 先天性TTP(血栓性血小板減少性紫斑病)の遺伝子解析.2016

    • Author(s)
      小亀浩市, 樋口(江浦)由佳.
    • Journal Title

      血栓と循環

      Volume: 印刷中

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Genetic, biochemical, and physiological approach to understanding the function of Herp and Derlin family proteins in ER-associated degradation machinery2017

    • Author(s)
      Koichi Kokame and Yuka Eura
    • Organizer
      ACCDiS Symposium 7 at XL Annual Meeting of the Chilean Society of Biochemistry and Molecular Biology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 小胞体膜タンパク質Derlin-3は小胞体ストレスによる小胞体関連分解(ERAD)複合体の変化に必要である2016

    • Author(s)
      樋口(江浦)由佳,池島裕子,宮田敏行,小亀浩市
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2016 Research-status Report
  • [Presentation] 補助人工心臓による高分子量VWFマルチマーの減少は循環開始直後に始まる.2015

    • Author(s)
      樋口(江浦)由佳,小亀浩市,水野敏秀,巽英介,宮田敏行.
    • Organizer
      第37回日本血栓止血学会学術集会
    • Place of Presentation
      甲府市
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
  • [Book] 生化学2017

    • Author(s)
      宮田敏行,樋口(江浦)由佳,杉本充彦
    • Total Pages
      10
    • Publisher
      公益社団法人 日本生化学会
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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