Study on motility fluctuation of small group of cytoplasmic dynein
| Project/Area Number |
15K18513
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAGI Hiroaki 奈良県立医科大学, 医学部, 講師 (10444514)
YAJIMA Junichiro 東京大学, 総合文化研究科, 准教授 (00453499)
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| Research Collaborator |
YAMAGUCHI Shin
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | ダイニン / 微小管 / 少数性 / ランダムウォーク / 集団運動 / 分子摩擦 |
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| Outline of Final Research Achievements |
Motility of motor protein’s small group has been studied. I observed movement of small groups of cytoplasmic dynein molecules which were linked with each other via a nanoparticle. Dynein small groups show unidirectional movement toward the minus end of the microtubule but biased random walk in the left-right direction. Focused on the biased random walk on the left-right axis, I analyzed the trajectories with the time-series analyses and Monte-Carlo simulation. Results suggest that dynein arrangement in small group and steric hindrance of neighbor dynein molecules should constrain directionality of stepping to the right or left, while the randomness should be due to number fluctuation and changes in arrangement of dynein molecules in a small group because of their binding-dissociation events on the microtubule.
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Report
(3 results)
Research Products
(6 results)
