In vitro reconstitution approach for understanding the cooperative transport by molecular motors
| Project/Area Number |
15K18524
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | National Institute of Information and Communications Technology |
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Principal Investigator |
Torisawa Takayuki 国立研究開発法人情報通信研究機構, 未来ICT研究所フロンティア創造総合研究室, 研究員 (60749406)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | ダイニン / キネシン / 細胞内輸送 / 分子モーター |
|---|
| Outline of Final Research Achievements |
Intracellular transport is an essential process for living cells. In eukaryotic cells, the transport is mainly mediated by the cooperative movements of molecular motors, enzymes which convert chemical energy from ATP hydrolysis to mechanical motion, along cytoskeletal filaments, such as actin and microtubule.
In this study, it is revealed that cytoplasmic dynein, which is responsible for the retrograde transport along microtubules, achieves the unidirectional transport through the rectification of one-dimensional diffusion along microtubule.
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Report
(4 results)
Research Products
(2 results)
