Ragulatory mechanism of selective autophagy
| Project/Area Number |
15K18530
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Shibutani Shusaku 山口大学, 共同獣医学部, 助教(テニュアトラック) (20534473)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Atg / オートファジー / 選択的オートファジー / ミトコンドリア / マイトファジー |
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| Outline of Final Research Achievements |
Selective autophagy is thought to maintain intracellular homeostasis by eliminating unwanted/dangerous materials. Although it has been shown that Atg proteins accumulate on the substrate in selective autophagy, events that happen afterwards are not clear. In this study, we discovered that the forced recruitment of LC3 to mitochondria is sufficient to induce mitochondrial degradation. We hypothesize that mitochondrial fission is induced at the contact site with the isolation membrane, which later engulfs the mitochondrial fragment generated by the fission. Moreover, this study suggests the existence of unidentified mitochondrial fission factors responsible for the mitochondrial fission during selective autophagy of mitochondria.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)2016
Author(s)
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Shibutani S. et al.
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Journal Title
Autophagy
Volume: 12
Pages: 1-222
Related Report
Int'l Joint Research
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