Elucidation of a force-dependent mechanism for maintaining radial size of epithelial tubes
| Project/Area Number |
15K18541
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | サイズ維持 / 上皮管 / 形態形成 / 数理モデル / イメージング / 器官形成 / 精巣上体 / メカノバイオロジー / バーテクスモデル / 蛍光ライブイメージング / バーテクスダイナミクスモデル / ライブイメージング / 多細胞力学応答 / 多細胞ライブイメージング / 多細胞動態の定量 / 多細胞動態の数理モデル |
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| Outline of Final Research Achievements |
For the understanding of mechanisms for size maintenance of biological tissues, I focused on an aspect of mechanics in mouse epididymal tubules during developmental process. I aimed at clarifying collective multicellular behaviors for maintaining diameter of epididymal tubules by using quantitative fluorescence imaging and mathematical modeling. The integrated approach revealed a mechanism of the size maintenance that constitutive cells within the tubules receive mechanical forces and respond by active cellular movement.
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Report
(4 results)
Research Products
(26 results)
