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Why and how terminally differentiated cells are kept quiescent

Research Project

Project/Area Number 15K18564
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Plant molecular biology/Plant physiology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Ikeuchi Momoko  国立研究開発法人理化学研究所, 環境資源科学研究センター, 基礎科学特別研究員 (00633570)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Keywords細胞分裂 / 細胞分化 / 再生 / 細胞リプログラミング / 細胞分化の維持機構 / エピジェネティクス
Outline of Final Research Achievements

Plant cells display remarkable plasticity, yet the potential needs to be controlled in the context of multicellular organisms. We have revealed that a histone modifier PRC2 plays key roles in the maintenance of cellular differentiation status. In this study, I further studied how PRC2 prevents proliferation of terminally differentiated cells. I also found an example of mitotic re-entry and cellular de-differentiation of fully differentiated cells, when plants are exposed to wounding stress.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 6 results,  Open Access: 2 results,  Acknowledgement Compliant: 4 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results) Remarks (1 results)

  • [Int'l Joint Research] CNRS(フランス)

    • Related Report
      2015 Research-status Report
  • [Journal Article] WIND1 promotes shoot regeneration through transcriptional activation of ESR1 in Arabidopsis.2017

    • Author(s)
      1.Iwase A, Harashima H, Ikeuchi M, Rymen B, Ohnuma M, Komaki S, Morohashi K, Kurata T, Nakata M, Ohme-Takagi M, Grotewold E, Sugimoto K
    • Journal Title

      Plant Cell

      Volume: 1 Issue: 1 Pages: 54-69

    • DOI

      10.1105/tpc.16.00623

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Plant regeneration: cellular origins and molecular mechanisms2016

    • Author(s)
      Momoko Ikeuchi, Yoichi Ogawa, Akira Iwase, Keiko Sugimoto
    • Journal Title

      Development

      Volume: 143 Issue: 9 Pages: 1442-1451

    • DOI

      10.1242/dev.134668

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 植物の再生現象における分化全能性制御の分子機構2016

    • Author(s)
      岩瀬哲, 池内桃子, 杉本慶子
    • Journal Title

      BSJ review

      Volume: 7 Pages: 161-176

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PRC2 represses dedifferentiation of mature somatic cells in Arabidopsis.2015

    • Author(s)
      Ikeuchi M, Iwase A, Rymen B, Harashima H, Shibata M, Ohnuma M, Breuer C, Morao AK, de Lucas M, De Veylder L., Goodrich J, Brady SM, Roudier F, Sugimoto K.
    • Journal Title

      Nature Plants

      Volume: 1 Issue: 7 Pages: 1-7

    • DOI

      10.1038/nplants.2015.89

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Control of plant cell differentiation by histone modification and DNA methylation2015

    • Author(s)
      Ikeuchi M, Iwase A, Sugimoto K
    • Journal Title

      Current Opinioin in Plant Biology

      Volume: 28 Pages: 60-67

    • DOI

      10.1016/j.pbi.2015.09.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] WIND1-based acquisition of regeneration competency in Arabidopsis and rapeseed2015

    • Author(s)
      Iwase A,Mita K,Nonaka S, Ikeuchi M, Koizuka C, Ohnuma M, Ezura H, Imamura J, Sugimoto K
    • Journal Title

      Journal of Plant Research

      Volume: 128 Issue: 3 Pages: 389-397

    • DOI

      10.1007/s10265-015-0714-y

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Wound-induced cellular reprogramming in plants2017

    • Author(s)
      Ikeuchi M
    • Organizer
      ITbM seminar
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Identification of novel regulator required for wound-induced cellular reprogramming in Arabidopsis thaliana2017

    • Author(s)
      Ikeuchi M, Iwase A, Sugimoto K
    • Organizer
      日本植物生理学会
    • Place of Presentation
      鹿児島大学(鹿児島県鹿児島市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Transcriptome and hormonal analysis of wound-induced callus formation in Arabidopsis2016

    • Author(s)
      Ikeuchi M, Iwase A, Kojima M, Sakakibara H, Sugimoto K
    • Organizer
      Cold Spring Harbor Asia
    • Place of Presentation
      淡路夢舞台(兵庫県神戸市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 分化を完了した植物細胞の脱分化と細胞分裂再開2016

    • Author(s)
      池内桃子
    • Organizer
      基生研研究会「細胞分化を誘導する細胞周期制御システム」
    • Place of Presentation
      基礎生物学研究所(愛知県岡崎市)
    • Year and Date
      2016-11-21
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Stress induced cellular reprogramming in plants2016

    • Author(s)
      Ikeuchi M
    • Organizer
      新学術領域環境記憶統合若手の会
    • Place of Presentation
      KKR熱海(静岡県熱海市)
    • Year and Date
      2016-10-12
    • Related Report
      2016 Annual Research Report
  • [Presentation] Epigenetic control of plant regeneration and stem cell formation2016

    • Author(s)
      Ikeuchi M, Iwase A, Sugimoto K
    • Organizer
      日本植物生理学会
    • Place of Presentation
      岩手大学(岩手・盛岡)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 植物細胞の分化可塑性およびその抑制機構2015

    • Author(s)
      池内桃子
    • Organizer
      日本植物学会
    • Place of Presentation
      朱鷺メッセ(新潟・新潟)
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] PRC2 represses dedifferentiation of mature somatic cells in Arabidopsis2015

    • Author(s)
      Ikeuchi M, Iwase A, Sugimoto K
    • Organizer
      FASEB meeting: Mechanisms of Plant Development
    • Place of Presentation
      Vermont, USA
    • Year and Date
      2015-08-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 植物が傷口で茎葉を再生させる仕組み

    • URL

      http://www.riken.jp/pr/press/2017/20170117_2/

    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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