Physiological significance of pineal neurosteroids and the circadian rhythms in their synthesis
Project/Area Number |
15K18571
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Morphology/Structure
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Research Institution | Showa University (2016) Waseda University (2015) |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 光環境 / 松果体 / ステロイド / 小脳 / アロプレグネノロン / PACAP / ニューロステロイド / 概日リズム / 下垂体アデニル酸シクラーゼ活性化ポリペプチド |
Outline of Final Research Achievements |
In this study, we sought to examine the action of pineal neurosteroids. Following pinealectomy, we found that the reduced concentration of allopregnanolone induced apoptosis in the Purkinje cells of the cerebellum. However, administration of allopregnanolone to pinealectomized chicks prevented apoptosis in these cells. Subsequently, we have demonstrated that mRNA expression of pituitary adenylate cyclase-activating polypeptide (PACAP), an endogenous neuroprotective factor, is decreased following pinealectomy in the developing cerebellum of chicks. These findings suggest that the neuroprotective effect of pineal allopregnanolone is associated with an increase in PACAP mRNA expression during the early stages of neuronal development. We therefore provide new evidence that pineal allopregnanolone may be involved in Purkinje cell survival mediated by PACAP action during development.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells.2017
Author(s)
Shishido Y, Baba T, Sato T, Shima Y, Miyabayashi K, Inoue M, Akiyama H, Kimura H, Kanal Y, Ishihara Y, Haraguchi S, Miyazaki A, Rozman D, Yamazaki T, Choi MH, Ohkawa Y, Suyama M, Morohashi KI
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 41912-41912
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Possible hormonal interaction for eliciting courtship behavior in the male newt, Cynops pyrrhogaster2015
Author(s)
Toyoda, F., Hasunuma, I., Nakada, T., Haraguchi, S., Tsutsui, K., Kikuyama, S.
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Journal Title
General and Comparative Endocrinology
Volume: 224
Pages: 96-103
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] 7α-Hydroxypregnenolone, a key neuronal modulator of locomotion, stimulates upstream migration by means of the dopaminergic system in salmon2015
Author(s)
Haraguchi S, Yamamoto Y, Suzuki Y, Hyung Chang J, Koyama T, Sato M, Mita M, Ueda H, Tsutsui K
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Journal Title
Sci Rep
Volume: 5
Issue: 1
Pages: 12546-12546
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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