The role of AMH in gonadal size
Project/Area Number |
15K18572
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Morphology/Structure
|
Research Institution | The University of Tokyo (2017-2018) Nagoya University (2016) National Institute for Basic Biology (2015) |
Principal Investigator |
Fujimori Chika 東京大学, 大気海洋研究所, 特任研究員 (50750775)
|
Project Period (FY) |
2015-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | メダカ / 卵巣 / 生殖細胞 / 生殖腺 / AMH |
Outline of Final Research Achievements |
In previous studies, anti-mullerian hormone (amh) signal deficient medaka hotei were isolated and they showed hyperactivation of germline stem cell division, resulting germ cell excess. I performed medaka ovarian cell culture and examined the character of cultured cells . After 14 days of cell culture, functional sperm were produced from cultured ovarian germ cells, suggesting that medaka adult ovaries have germ cells with potential to differentiate into both oocytes and sperm.
|
Academic Significance and Societal Importance of the Research Achievements |
今回の研究によって、どの発達段階の生殖細胞が卵巣器官を形成することができるのか、また、成体の卵巣内にある生殖細胞の中でどの分化段階の生殖細胞まで精子・卵どちらにも分化できる能力を持つのかを示すことができた。今回確立した培養実験系はどのような因子が精子・卵への分化に寄与しているのかをスクリーニングするための系としても利用できる可能性がある。
|
Report
(5 results)
Research Products
(3 results)