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Neurophysiological analysis of dopamine dependnent odor preference changes

Research Project

Project/Area Number 15K18577
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Animal physiology/Animal behavior
Research InstitutionTokyo Metropolitan Institute of Medical Science

Principal Investigator

NAGANOS Shintaro  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主任研究員 (30631965)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsドーパミン / 行動の可塑性 / 学習記憶 / 電気化学 / ショウジョウバエ / 匂い嗜好の変化 / 匂い連合学習
Outline of Final Research Achievements

Experience-dependent preference changes are found in various animals from mammals to insects. However, the detail of its molecular and cellular mechanism is still unclear. In this study, we employed olfactory associations in Drosophila melanogaster and investigated neurophysiological processes of experience dependent odor preference changes. We found that monoamine neurotransmitter, dopamine, and dopaminergic neurons were required for preference behavioral plasticity. Then, we employed electrochemical method and calcium imaging to detect dopamine release and neural activities of dopaminergic neuron, respectively. As results, we have identified that each brain regions, which regulate odor preference behavior, have unique dopamine release manners.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Learning defects in Drosophila growth restricted chico mutants are caused by attenuated adenylyl cyclase activity2016

    • Author(s)
      Naganos S, Ueno K, Horiuchi J, Saitoe M
    • Journal Title

      Molecular Brain

      Volume: Apr 6;9:37 Issue: 1 Pages: 1-10

    • DOI

      10.1186/s13041-016-0217-3

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 電気化学的手法を用いた匂い連合学習を担う単一ドーパミン神経機能の解明2017

    • Author(s)
      長野 慎太郎、齊藤実
    • Organizer
      第40回日本分子生物科学会例会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Dopamine receptor activities regulate learning-dependent odor preference changes in Drosophila2015

    • Author(s)
      Shintaro Naganos, Kohei Ueno, Junjiro Horiuchi, Minoru Saitoe.
    • Organizer
      北米神経科学大会
    • Place of Presentation
      アメリカ シカゴ
    • Year and Date
      2015-10-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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