Understanding the relationship between aerobic energy metabolisms and cell cycle progression in eukaryotes.
| Project/Area Number |
15K18588
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Evolutionary biology
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 真核藻類 / 概日リズム / 細胞周期 / 遺伝子改変 / 植物 / レドックス / 藻類 / 光合成 / 葉緑体 / 細胞周期進行 |
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| Outline of Final Research Achievements |
Mitochondria and chloroplasts perform highly efficient energy metabolisms, respiration and photosynthesis, respectively, in eukaryotes. The aerobic energy metabolisms, however, are also main generators of reactive oxygen species and can damage cells. It has been poorly known how eukaryotic cells coordinate the aerobic energy metabolisms for safe cell proliferation during a daily cycle. Eukaryotic algae grow during the daytime. In contrast, the cell cycle progression is restricted to the night when photosynthesis does not operate. This temporal separation protects S- and M-phase cells from photosynthetic oxidative stress. Circadian rhythms are believed to control this temporal separation. We demonstrated that change in photosynthetic activity resets the circadian rhythms, which suggests that the timing of cell cycle progression, which is regulated by circadian rhythms, are probably determined by interaction between the molecular clock in a host and retrograde signals from endosymbionts.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Glycosyltransferase MDR1 assembles a dividing ring for mitochondrial proliferation comprising polyglucan nanofilaments2017
Author(s)
Yoshida Yamato, Kuroiwa Haruko, Shimada Takashi, Yoshida Masaki, Ohnuma Mio, Fujiwara Takayuki, Imoto Yuuta, Yagisawa Fumi, Nishida Keiji, Hirooka Shunsuke, Misumi Osami, Mogi Yuko, Akakabe Yoshihiko, Matsushita Kazunobu, Kuroiwa Tsuneyoshi
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Journal Title
Proceedings of the National Academy of Sciences
Volume: 114
Issue: 50
Pages: 13284-13289
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Acidophilic green algal genome provides insights into adaptation to an acidic environment2017
Author(s)
Hirooka, S., Hirose, Y., Kanesaki, Y., Higuchi, S., Fujiwara, T., Onuma, R., Era, A., Ohbayashi, R., Uzuka, A., Nozaki, H., Yoshikawa, H., and Miyagishima, S.
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Journal Title
Proc. Natl. Acad. Sci. USA.
Volume: 114
Issue: 39
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Development of a double nuclear gene-targeting method by two-step transformation based on a newly established chloramphenicol-selection system in the red alga Cyanidioschyzon merolae2017
Author(s)
Fujiwara, T., Ohnuma, M., Kuroiwa, T., Ohbayashi, R., Hirooka, S.and Miyagishima, S.
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Journal Title
Front. Plant Sci.
Volume: 8
Pages: 343-343
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Book] Cyanidioschyzon merolae A New Model Eukaryote for Cell and Organelle Biology Chapter 72017
Author(s)
Kuroiwa, T., Miyagishima, S., Matsunaga, S., Sato, N., Nozaki, H., Tanaka, K., Misumi, O. (Eds.)
Total Pages
365
Publisher
Springer
ISBN
9789811061004
Related Report
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[Book] Cyanidioschyzon merolae A New Model Eukaryote for Cell and Organelle Biology Chapter 112017
Author(s)
Kuroiwa, T., Miyagishima, S., Matsunaga, S., Sato, N., Nozaki, H., Tanaka, K., Misumi, O. (Eds.)
Total Pages
365
Publisher
Springer
ISBN
9789811061004
Related Report
