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Study about the molecular mechanism of iron transport and homeostasis through the secretion of Mugineic acid family phytosiderophores and Nicotianamine

Research Project

Project/Area Number 15K18658
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Plant nutrition/Soil science
Research InstitutionMeiji Gakuin University

Principal Investigator

Nozoye Tomoko  明治学院大学, 教養教育センター, 講師 (90590208)

Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords鉄 / ムギネ酸類 / ニコチアナミン / トランスポーター / イネ科植物 / ムギネ酸 / ENA1 / イネ / エリアンサス / サツマイモ / オリーブ / 金属栄養
Outline of Final Research Achievements

Mugineic acid family phytosiderophores (MAs) and nicotianamine (NA) are kinds of amino acids, which are involved in iron (Fe) uptake and transport in planta. In this study, the functions of the transporter protein ‘TOM2 and ENA1’ and the enzymatic proteins ‘DMAS’ have been characterized. Also, it was revealed that the increase of MAs and/or NA can both confer tolerance against Fe deficiency and increase Fe concentrations in the useful crops such as sweet potato and erianthus. In addition, it was showed that the olive, which has been known as a Fe deficiency-tolerate crop, has the homologus genes to the MAs biosynthetic enzymatic genes, and produces MAs in addition to NA.

Academic Significance and Societal Importance of the Research Achievements

全ての生物に取って必須な金属栄養素である鉄は、土壌中に豊富に存在するが、その大部分が水に溶けにくい三価鉄として存在しているため植物は利用できない。また、我々人が食物から摂取する鉄は究極的には植物が土壌から獲得し、可食部に蓄積したものに由来する。作物増産及び人の健康を向上するためには植物の鉄獲得の分子機構を理解して増強することが求められる。本研究の成果は、作物の鉄欠乏耐性能力及び鉄含有量を増強する技術の開発につながると期待される。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (18 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Funded Workshop (2 results)

  • [Int'l Joint Research] IPK/バイロイト大学(ドイツ)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Characterization of the Nicotianamine Exporter ENA1 in Rice2019

    • Author(s)
      Nozoye Tomoko、von Wiren Nicolaus、Sato Yoshikatsu、Higashiyama Tetsuya、Nakanishi Hiromi、Nishizawa Naoko K.
    • Journal Title

      Frontiers in Plant Science

      Volume: 10 Pages: 1-1

    • DOI

      10.3389/fpls.2019.00502

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis by OsNAS3 Is Important for Mitigating Iron Excess Stress in Rice.2019

    • Author(s)
      Aung MS, Masuda H, Nozoye T,Kobayashi T, Jeon J-S, An G, Nishizawa NK.
    • Journal Title

      Frontiers in Plant Sciences

      Volume: 10 Pages: 660-660

    • DOI

      10.3389/fpls.2019.00660

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Iron transport and its regulation in plants2019

    • Author(s)
      Kobayashi Takanori、Nozoye Tomoko、Nishizawa Naoko K.
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 133 Pages: 11-20

    • DOI

      10.1016/j.freeradbiomed.2018.10.439

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Nicotianamine Synthase Gene Is a Useful Candidate for Improving the Nutritional Qualities and Fe-Deficiency Tolerance of Various Crops2018

    • Author(s)
      Nozoye Tomoko
    • Journal Title

      Frontiers in Plant Science

      Volume: 9 Pages: 340-340

    • DOI

      10.3389/fpls.2018.00340

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bioenergy grass [Erianthus ravennae (L.) Beauv.] secretes two members of mugineic acid family phytosiderophores which involved in their tolerance to Fe deficiency2017

    • Author(s)
      Nozoye Tomoko、Aung May Sann、Masuda Hiroshi、Nakanishi Hiromi、Nishizawa Naoko K.
    • Journal Title

      Soil Science and Plant Nutrition

      Volume: 63 Issue: 6 Pages: 543-552

    • DOI

      10.1080/00380768.2017.1394168

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of barley nicotianamine synthase 1 confers tolerance in the sweet potato to iron deficiency in calcareous soil.2017

    • Author(s)
      T. Nozoye, M. Otani, T. Senoura, H. Nakanishi, N.K. Nishizawa
    • Journal Title

      Plant and Soil

      Volume: 印刷中 Issue: 1-2 Pages: 1-14

    • DOI

      10.1007/s11104-016-3134-4

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The detection of endogenous 2’-deoxymugineic acid in olives (Olea europaea L.) indicates the biosynthesis of mugineic acid family phytosiderophores in non-graminaceous plants.2016

    • Author(s)
      M. Suzuki, T. Nozoye, S. Nagasaka, H. Nakanishi, N.K. Nishizawa, S. Mori
    • Journal Title

      Soil Science and Plant Nutrition

      Volume: 62 Issue: 5-6 Pages: 481-488

    • DOI

      10.1080/00380768.2016.1230724

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The phytosiderophore efflux transporter TOM2 is involved in metal transport in rice2015

    • Author(s)
      Tomoko Nozoye, Seiji Nagasaka, Takanori Kobayashi, Yuki Sato, Nobuyuki Uozumi, Hiromi Nakanishi, Naoko K. Nishizawa
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 290 Issue: 46 Pages: 27688-27699

    • DOI

      10.1074/jbc.m114.635193

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Characterization of the nicotianamine exporter ENA1 in rice2020

    • Author(s)
      Tomoko Nozoye1,2, Nicolaus von Wirén, Yoshikatsu Sato, Tetsuya Higashiyama, Hiromi Nakanishi, Naoko K. Nishizawa
    • Organizer
      第61回日本植物生理学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] イネのニコチアナミン排出型トランスポーターENA1の 植物における機能の解析2019

    • Author(s)
      野副 朋子, von Wirén Nicolaus, 佐藤 良勝, 東山 哲也, 中西 啓仁, 西澤 直子
    • Organizer
      日本土壌肥料学会2019年度静岡大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The study of iron nutrition in the graminaceous plants2019

    • Author(s)
      野副 朋子
    • Organizer
      第14回ムギ類研究会
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of iron uptake strategy in Bioenergy grass [Erianthus ravennae (L.) Beauv.]2018

    • Author(s)
      Tomoko Nozoye, May Sann Aung, Hiroshi Masuda, Hiromi Nakanishi, Naoko K Nishizawa
    • Organizer
      19th International Symposium on Iron Nutrition and Interaction in Plants
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Barley nicotianamine synthase 1 (HvNAS1) gene is usuful candidate to improve nutritional qualities and agricultural productivity in soybean and sweet potato2017

    • Author(s)
      Tomoko Nozoye, Takeshi Senoura, Suyoen Kim, Yuske Kakei, Michiko Takahashi, Motoyasu Otani, Hiromi Nakanishi, Naoko K. Nishizawa
    • Organizer
      XVIII International Plant Nutrition Colloquium (IPNC)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 植物の金属キレーターニコチアナミン及びムギネ酸類の分泌機構2016

    • Author(s)
      野副 朋子
    • Organizer
      第40回日本鉄バイオサイエンス学会
    • Place of Presentation
      名古屋大学(愛知県、名古屋市)
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Overexpression of barley nicotianamine synthase 1 (HvNAS1) confer tolerance to Fe deficiency on calcareous soil in soybean and sweet potato.2016

    • Author(s)
      Tomoko Nozoye, Takeshi Senoura, Suyoen Kim, Yuske Kakei, Michiko Takahashi, Motoyasu Otani, Hiromi Nakanishi, Naoko K. Nishizawa
    • Organizer
      18th International Symposium on Iron Nutrition and Interaction in Plants
    • Place of Presentation
      Universidad Autónoma de Madrid (Madrid, Spain)
    • Year and Date
      2016-05-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Funded Workshop] XVIII International Plant Nutrition Colloquium (IPNC)2017

    • Related Report
      2017 Research-status Report
  • [Funded Workshop] 18th International Symposium on Iron Nutrition and Interaction in Plants2016

    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2016-05-30
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2022-11-04  

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