Research Project
Grant-in-Aid for Young Scientists (B)
In this study, JAZ subtype-selective agonists, which selectively activate useful functions among diverse physiological roles by jasmonic acids signaling, are developed based on coronatine which is a mimic of jasmonoyl-L-isoleucine with potent activities. A lead compound used for JAZ selective agonist development was found using an evaluation system of pull-down assay system COI1-JAZ interaction using JAZ fragment peptide which is a binding domain with COI1 of JAZ. Based on the knowledge, we designed several compounds that are thought to be more selective improvement by in silico docking study. By a similar pull-down assay, two subtype-selective agonists that bind to some of JAZ were found among them.
All 2017 2016 2015 Other
All Int'l Joint Research (1 results) Journal Article (10 results) (of which Int'l Joint Research: 2 results, Peer Reviewed: 10 results, Open Access: 6 results, Acknowledgement Compliant: 4 results) Presentation (28 results) (of which Invited: 1 results)
PLoS ONE
Volume: 12(3) Issue: 3 Pages: e0173441-e0173441
10.1371/journal.pone.0173441
Bioscience, Biotechnology, and Biochemistry
Volume: 81 Issue: 2 Pages: 249-255
10.1080/09168451.2016.1246174
Nature Commun.
Volume: 7 Issue: 1 Pages: 1-11
10.1038/ncomms13245
Plant Molecular Biology
Volume: 印刷中 Issue: 4-5 Pages: 533-547
10.1007/s11103-016-0486-3
Bioorg. Med. Chem. Lett.
Volume: 26 Issue: 1 Pages: 9-14
10.1016/j.bmcl.2015.11.055
RSC Adv.
Volume: 6 Issue: 23 Pages: 19404-19412
10.1039/c5ra20676f
Nature Communications
Volume: 6 Issue: 1 Pages: 6095-6095
10.1038/ncomms7095
Org. Biomol. Chem.
Volume: 13 Issue: 1 Pages: 55-58
10.1039/c4ob02106a
Plant Cell Physiol.
Volume: 56 Issue: 4 Pages: 779-789
10.1093/pcp/pcv006
Plant Mol. Biol.
Volume: 88 Issue: 1-2 Pages: 165-176
10.1007/s11103-015-0315-0
