Effect of dietary sphingolipids on the absorption of nutrients

Research Project

Project/Area Number	15K18693
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Food science
Research Institution	Hokkaido University
Principal Investigator	SAKAI Shota 北海道大学, 先端生命科学研究院, 特任助教 (60611720)
Project Period (FY)	2015-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000) Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	スフィンゴ脂質 / 栄養素 / トランスポーター
Outline of Final Research Achievements	Glucosylceramides and their sphingoid bases were purified from various food materials and the effect of these sphingolipids on the mRNA expression of the transporter of various nutrients was investigated. The levels of mRNA of transporters related to minerals, such as calcium and magnesium, were significantly increased by the treatment of glucosylceramide and sphingoid base from plants and fungi. Futhermore, These sphingolipids facilitated the dimerization of CTR1 protein, which is involved in the incorporation of copper, and increased the contents of glycosylated iron transporter DMT-1 protein.

Report

(3 results)