The effect of mitochondrial oxidative stress on the hypertension induced by dietary sodium intake.
Project/Area Number |
15K18694
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Food science
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Research Institution | Tohoku University |
Principal Investigator |
OHSAKI YUSUKE 東北大学, 医学系研究科, 助教 (40509212)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 食塩 / 高血圧 / 酸化ストレス / 腎障害 / ミトコンドリア / ナトリウム貯留 / 腎臓髄質血流 / 体液貯留 / ナトリウム / 腎臓 / 腎臓生理学 / 利尿薬 / 腎髄質血流量 |
Outline of Final Research Achievements |
Oxidative stress production in the renal medullary region contributes to increase blood pressure. The contribution of NAD(P)H oxidase derived oxidative stress in the renal medullary region has been well investigated, while the contribution of mitochondrial oxidative stress production is still unclear. We fed high salt diet to salt sensitive hypertension model animals, and infused TEMPOL or MitoTEMPO simultaneously. High salt diet treatment significantly increased systolic blood pressure and urinary albumin excretion. Treatment with TEMPO and MitoTEMPO tended to attenuate the increase of blood pressure and urinary albumin excretion, however did not reached to significant level.
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Report
(4 results)
Research Products
(35 results)
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[Journal Article] Acidic organelles mediate TGF-β1-induced cellular fibrosis via (pro)renin receptor and vacuolar ATPase trafficking in human peritoneal mesothelial cells.2018
Author(s)
1: Oba-Yabana I, Mori T, Takahashi C, Hirose T, Ohsaki Y, Kinugasa S, Muroya Y, Sato E, Nguyen G, Piedagnel R, Ronco PM, Totsune K, Ito S
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Journal Title
Scientific Reports
Volume: 8
Issue: 1
Pages: 2648-2648
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] ANGIOTENSIN INDEPENDENT ROLE OF (PRO)RENIN RECEPTOR IN HUMAN PERITONEAL MESOTHELIAL CELLS.2015
Author(s)
Ikuko Yabana, Takefumi Mori, Chika Takahashi, Yusuke Ohsaki, Emiko Sato, Takuo Hirose, Geneviève Nguyen, Rémi Piedagnel, Pierre Ronco, Sadayoshi Ito
Organizer
EURO PD 2015
Place of Presentation
Krakow, Poland
Year and Date
2015-10-02
Related Report
Int'l Joint Research
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[Presentation] Role of long-term treatment of tolvaptan on left ventricular mass index in patients undergoing peritoneal dialysis.2015
Author(s)
Kenji Koizumi, Takefumi Mori, Yusuke Ohsaki, Ikuko Ohba, Shinichi Sato, Satoshi Shimada, Eri Naganuma, Naho Kurasawa, Mihoko Tsuchikawa, Sadayoshi Ito.
Organizer
APCM-ISPD 2015
Place of Presentation
Daegu, Korea
Year and Date
2015-09-17
Related Report
Int'l Joint Research
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