| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Oxidative stress production in the renal medullary region contributes to increase blood pressure. The contribution of NAD(P)H oxidase derived oxidative stress in the renal medullary region has been well investigated, while the contribution of mitochondrial oxidative stress production is still unclear. We fed high salt diet to salt sensitive hypertension model animals, and infused TEMPOL or MitoTEMPO simultaneously. High salt diet treatment significantly increased systolic blood pressure and urinary albumin excretion. Treatment with TEMPO and MitoTEMPO tended to attenuate the increase of blood pressure and urinary albumin excretion, however did not reached to significant level.
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