| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Siphonaxanthin is one of the major carotenoids in some edible green algae, such as Caulerpa lentillifera. In this study, we evaluated an anti-inflammatory effect of siphonaxanthin against a dinitrofluorobenzene (DNFB)-induced mouse dermatitis model. Orally administration of siphonaxanthin significantly suppressed ear swelling induced by DNFB. Surprisingly, metabolites of siphonaxanthin were more accumulated in the skin than the intact form. Hence, it is required to evaluate their biological activities including an anti-inflammatory effect. We also evaluate combined effects between siphonaxanthin and the other well-known anti-allergic compounds. We unfortunately could not find out some anti-allergic compounds which enhanced the anti-inflammatory activity or bioavailability of siphonaxanthin. However, we found that vitamin E such as α-tocopherol inhibits the uptake of siphonaxanthin by differentiated Caco-2 cells.
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