| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Phase-II conjugation of phenolic compounds is generally thought to result in their inactivation. The current study aimed to investigate whether sulfated form of certain phenolic compound(s) could demonstrate any biological functions as the model. Antioxidative effects of 1-naphthyl sulfate (1-NapS) and 1-naphthyl sulfate (2-NapS), in comparison with their unsulfated counterparts 1-Nap and 2-Nap, using established free radical scavenging assays. The results obtained indicated that sulfate conjugation of the Nap isomers did not always result in the decrease of their antioxidant activity, and the antioxidant activity that remained appeared to depend on the position of sulfation.
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