Stadies on IgA induction in the large intestine by vitamin A
| Project/Area Number |
15K18706
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Toyama Prefectural Institute. for Pharmaceutical Research. |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | IgA / ビタミンA / IL-5 |
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| Outline of Final Research Achievements |
IgA is a key regulator of the gut microbiota. In this study, we examined that the role of vitamin A in IgA production in the large intestine. By using vitamin A deficient IL-5 reporter mice, we found that vitamin A facilitated the IL-5 expression by ILC2s and contributed to maintaining sufficient number of eosinophils in the large intestine. In addition, we showed the possibility that IL-5-producing ILC2s regulated the amount of T cell-independent IgA and controlled the composition of the gut microbiota through the regulation of eosinophil homeostasis.
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Report
(4 results)
Research Products
(7 results)
