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Stadies on IgA induction in the large intestine by vitamin A

Research Project

Project/Area Number 15K18706
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Food science
Research InstitutionToyama Prefectural Institute. for Pharmaceutical Research.

Principal Investigator

Yanagibashi Tsutomu  富山県薬事研究所, その他部局等, 主任研究員 (60710887)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsIgA / ビタミンA / IL-5
Outline of Final Research Achievements

IgA is a key regulator of the gut microbiota. In this study, we examined that the role of vitamin A in IgA production in the large intestine. By using vitamin A deficient IL-5 reporter mice, we found that vitamin A facilitated the IL-5 expression by ILC2s and contributed to maintaining sufficient number of eosinophils in the large intestine. In addition, we showed the possibility that IL-5-producing ILC2s regulated the amount of T cell-independent IgA and controlled the composition of the gut microbiota through the regulation of eosinophil homeostasis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (3 results) Remarks (2 results)

  • [Journal Article] Elimination of eosinophils using anti-IL-5 receptor alpha antibodies effectively suppresses IL-33-mediated pulmonary arterial hypertrophy2018

    • Author(s)
      Ikutani Masashi、Ogawa Shinya、Yanagibashi Tsutomu、Nagai Terumi、Okada Kazuki、Furuichi Yoko、Takatsu Kiyoshi
    • Journal Title

      Immunobiology

      Volume: 223 Issue: 6-7 Pages: 486-492

    • DOI

      10.1016/j.imbio.2017.12.002

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-52017

    • Author(s)
      Yanagibashi T、Satoh M、Nagai Y、Koike M、Takatsu K
    • Journal Title

      Cytokine

      Volume: 98 Pages: 59-70

    • DOI

      10.1016/j.cyto.2016.11.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] IL-5-producing ILC2s in the large intestine contribute to T cell-independent IgA production through theregulation of eosinophil homeostasis.2017

    • Author(s)
      Tsutomu Yanagibashi、 Masashi Ikutani、Yoshinori Nagai、Kiyoshi Takatsu
    • Organizer
      第46回日本免疫学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] IL-5-producing ILC2s regulate T cell-independent IgA production in the large intestine2016

    • Author(s)
      Tsutomu Yanagibashi, Masashi Ikutani, Yoshinori Nagai, Kiyoshi Takatsu
    • Organizer
      4th Toyama-Basel Joint Symposium
    • Place of Presentation
      University of Basel(スイス)
    • Year and Date
      2016-08-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Role of IL-5-producing ILC2s in the T cell independent-IgA production in the intestine2015

    • Author(s)
      Yanagibashi Tsutomu, Masashi Ikutani, Yoshinori Nagai, Kiyoshi Takatsu
    • Organizer
      第44回 日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道、札幌市)
    • Year and Date
      2015-11-17
    • Related Report
      2015 Research-status Report
  • [Remarks] 富山県薬事総合研究開発センター

    • URL

      http://www.pref.toyama.jp/branches/1285/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 富山大学大学院医学薬学研究部(医学)免疫バイオ・創薬探索研究講座

    • URL

      http://www.med.u-toyama.ac.jp/immbio/index.html

    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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