Stadies on IgA induction in the large intestine by vitamin A

• Project/Area Number: 15K18706
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Toyama Prefectural Institute. for Pharmaceutical Research.
• Principal Investigator: Yanagibashi Tsutomu 富山県薬事研究所, その他部局等, 主任研究員 (60710887)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: IgA / ビタミンA / IL-5

Outline of Final Research Achievements

IgA is a key regulator of the gut microbiota. In this study, we examined that the role of vitamin A in IgA production in the large intestine. By using vitamin A deficient IL-5 reporter mice, we found that vitamin A facilitated the IL-5 expression by ILC2s and contributed to maintaining sufficient number of eosinophils in the large intestine. In addition, we showed the possibility that IL-5-producing ILC2s regulated the amount of T cell-independent IgA and controlled the composition of the gut microbiota through the regulation of eosinophil homeostasis.

Research Products

• [Journal Article] Elimination of eosinophils using anti-IL-5 receptor alpha antibodies effectively suppresses IL-33-mediated pulmonary arterial hypertrophy (2018)
  • Author(s): Ikutani Masashi、Ogawa Shinya、Yanagibashi Tsutomu、Nagai Terumi、Okada Kazuki、Furuichi Yoko、Takatsu Kiyoshi
  • Journal Title: Immunobiology Volume: 223 Issue: 6-7 Pages: 486-492
  • DOI: 10.1016/j.imbio.2017.12.002
  • Peer Reviewed / Open Access
• [Journal Article] Allergic diseases: From bench to clinic - Contribution of the discovery of interleukin-5 (2017)
  • Author(s): Yanagibashi T、Satoh M、Nagai Y、Koike M、Takatsu K
  • Journal Title: Cytokine Volume: 98 Pages: 59-70
  • DOI: 10.1016/j.cyto.2016.11.011
  • Peer Reviewed
• [Presentation] IL-5-producing ILC2s in the large intestine contribute to T cell-independent IgA production through theregulation of eosinophil homeostasis. (2017)
  • Author(s): Tsutomu Yanagibashi、 Masashi Ikutani、Yoshinori Nagai、Kiyoshi Takatsu
  • Organizer: 第46回日本免疫学会学術集会
• [Presentation] IL-5-producing ILC2s regulate T cell-independent IgA production in the large intestine (2016)
  • Author(s): Tsutomu Yanagibashi, Masashi Ikutani, Yoshinori Nagai, Kiyoshi Takatsu
  • Organizer: 4th Toyama-Basel Joint Symposium
  • Place of Presentation: University of Basel（スイス）
  • Year and Date: 2016-08-25
• [Presentation] Role of IL-5-producing ILC2s in the T cell independent-IgA production in the intestine (2015)
  • Author(s): Yanagibashi Tsutomu, Masashi Ikutani, Yoshinori Nagai, Kiyoshi Takatsu
  • Organizer: 第44回 日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター(北海道、札幌市）
  • Year and Date: 2015-11-17
• [Remarks] 富山県薬事総合研究開発センター
  • URL: http://www.pref.toyama.jp/branches/1285/
• [Remarks] 富山大学大学院医学薬学研究部（医学）免疫バイオ・創薬探索研究講座
  • URL: http://www.med.u-toyama.ac.jp/immbio/index.html