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Exploring transcription factors regulating embryonic metabolism in teleost fish

Research Project

Project/Area Number 15K18741
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Aquatic life science
Research InstitutionKitasato University (2016-2017)
University of Miyazaki (2015)

Principal Investigator

Furukawa Fumiya  北里大学, 海洋生命科学部, 助教 (80750281)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords発生 / 代謝 / ゼブラフィッシュ / 魚類 / 転写調節因子 / 糖 / 転写因子 / 糖代謝 / yolk syncytial layer
Outline of Final Research Achievements

In the processes of aquaculture, seedling production often faces mass mortality of developing fish. Although developing fish should metabolize various nutrients, limited knowledge is available regarding this topic. We focused on transcription factors normally found in adult livers and assessed their expression in developing zebrafish. Some of the transcription factor genes were expressed in zebrafish embryos, and their expression levels were changed in response to stressors, such as low oxygen, low temperature, low pH. These results suggest that developing fish embryos and larvae have abilities to adjust their metabolism to cope with external stresses.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Int'l Joint Research] Academia Sinica/National Taiwan Normal University(Taiwan)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] In vivo and in vitro effects of high-K+ stress on branchial expression of ROMKa in seawater-acclimated Mozambique tilapia2015

    • Author(s)
      Furukawa F, Watanabe S, Seale AP, Breves JP, Lerner DT, Grau EG, Kaneko T
    • Journal Title

      Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiolgy

      Volume: 187 Pages: 111-118

    • DOI

      10.1016/j.cbpa.2015.05.017

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Induction of phosphoenolpyruvate carboxykinase (PEPCK) during acute acidosis and its role in acid secretion by V-ATPase-expressing ionocytes2015

    • Author(s)
      Furukawa F, Tseng YC, Liu ST, Chou YL, Lin CC, Sung PH, Uchida K, Lin LY, Hwang PP
    • Journal Title

      International Journal of Biological Sciences

      Volume: 11 Issue: 6 Pages: 712-725

    • DOI

      10.7150/ijbs.11827

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] アワビ類の胚発生過程における糖新生とグリコーゲンの代謝について2018

    • Author(s)
      小山夢玄、古賀由香、古川史也、森山俊介、奥村誠一
    • Organizer
      平成30年度日本水産学会春季大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ゼブラフィッシュYolk syncytial layer (YSL)に発現する転写調節因子の探索2017

    • Author(s)
      伊良知正太郎、古川史也、香川浩彦、内田勝久
    • Organizer
      平成29年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学、東京都 港区
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 卵黄代謝とアワビ組織再生に関する研究の進展と今後の妄想2017

    • Author(s)
      古川史也
    • Organizer
      ユニークな少数派実験動物を扱う若手が最先端アプローチを勉強する会
    • Related Report
      2017 Annual Research Report
  • [Presentation] サクラマス発生過程の卵黄利用とアワビの組織再生2016

    • Author(s)
      古川史也
    • Organizer
      ユニークな少数派実験動物を扱う若手が最先端アプローチを勉強する会
    • Place of Presentation
      岡崎コンファレンスセンター、愛知県 岡崎市
    • Year and Date
      2016-08-22
    • Related Report
      2016 Research-status Report
  • [Presentation] ゼブラフィッシュ幼生におけるPEPCK経由糖新生は酸排出を促進する2015

    • Author(s)
      古川史也, Tseng YC, Liu ST, Chou YL, Sung PH, 内田勝久, Lin LY, Hwang PP
    • Organizer
      日本動物学会 第86回新潟大会
    • Place of Presentation
      朱鷺メッセ、新潟
    • Year and Date
      2015-09-19
    • Related Report
      2015 Research-status Report
  • [Presentation] Phosphoenolpyruvate carboxykinase (PEPCK)-mediated gluconeogenesis accelerates acid secretion by H+-ATPase-expressing ionocytes during acidosis2015

    • Author(s)
      Furukawa F, Tseng YC, Liu ST, Chou YL, Lin CC, Sung PH, Uchida K, Lin LY, Hwang PP
    • Organizer
      The 9th International Congress of Comparative Physiology and Biochemistry From Molecule to Macrophysiology
    • Place of Presentation
      Jagiellonian University, Krakow, Poland
    • Year and Date
      2015-08-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 魚類における卵黄の利用に関する生理学的研究2015

    • Author(s)
      古川史也
    • Organizer
      ユニークな少数派実験動物を扱う若手が酸先端アプローチを勉強する会
    • Place of Presentation
      岡崎コンファレンスセンター、愛知
    • Year and Date
      2015-08-19
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2022-08-18  

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