| Project/Area Number |
15K18767
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kusama Kazuya 東京大学, 大学院農学生命科学研究科(農学部), 特任助教 (30579149)
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| Research Collaborator |
IMAKAWA Kazuhiko 東京大学, 大学院農学生命科学研究科, 教授 (00291956)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 着床 / IFNT / ウシ / エクソソーム / 免疫寛容 / 妊娠免疫 |
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| Outline of Final Research Achievements |
We demonstrated novel regulatory mechanisms by which bovine IFNTs were regulated by transcriptional factors TEAD2, TEAD4 and YAP1. In addition, two IFNTs, IFNT2 and IFN-tau-c1, were regulated by different transcription factors. In this study, IFNT up-regulated immune- and antigen presentation-related genes in bovine endometrium, indicating that IFNT regulated immune system against conceptus in pre-implantation endometrium.
We identified that conceptus-derived exosome exists in bovine and ovine endometrial lumen, and its components differed during peri-implatantion periods. We further indicated that conceptus-derived exosome regulated endometrial condition essential for the conceptus implantation in pre-implantation periods.
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