Activin A as a coordinator of oviductal environment: local action for successful fertilization and establishment of pregnancy in oviducts
| Project/Area Number |
15K18771
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | Okayama University |
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Principal Investigator |
Yamamoto Yuki 岡山大学, 環境生命科学研究科, 助教 (20645345)
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| Research Collaborator |
OKUDA Kiyoshi
KIMURA Koji
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 卵管 / 家畜 / アクチビン / アポトーシス / 上皮細胞 / アクチビンA / Smad2/3 / フォリスタチン |
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| Outline of Final Research Achievements |
Environment in mammalian oviducts is highly regulated by many endocrine/paracrine/autocrine factors for fertilization and early embryonic development. The present study has revealed that 1) activin A, a local factor, is constantly present in oviductal lumen, 2) oviductal epithelial cells are target of activin A, and 3) mRNA expression of activin receptor is lowest on a day of ovulation in bovine oviduct. In addition, 4) inhibition of activin signal transduction increased pro-apoptotic gene expression in isthmic epithelial cells of bovine oviduct.
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Report
(3 results)
Research Products
(3 results)
