Is Reston ebolavirus an Asian virus? - Epidemiological investigation in Southern Africa

• Project/Area Number: 15K18777
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Veterinary medical science
• Research Institution: Okayama University
• Principal Investigator: Ogawa Hirohito 岡山大学, 医歯薬学総合研究科, 助教 (80455237)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: エボラウイルス / レストンエボラウイルス / フィロウイルス / ブタ / ザンビア共和国 / アフリカ / 人獣共通感染症 / 血清疫学

Outline of Final Research Achievements

Ebolavirus causes severe hemorrhagic fever. Reston ebolavirus which is one of ebolavirus species has thus far been found only in Asia. Our previous serological surveillance of filoviruses in fruit bats migrating to Zambia suggested that Reston ebolavirus or Reston-like virus existed in Africa. In this study, we carried out a serological survery to detect Reston ebolavirus-specific IgG antibodies in pig, which is suspected to be one of natural hosts, in Zambia. A total of 1082 swine serum samples were screened for IgG antibodies specific to the Reston ebolavirus by ELISA method, and the OD values obtained were analyzed statistically. Ten samples were found to be IgG positive, suggesting that Reston ebolavirus or Reston-like virus have been introduced into the pig population in Zambia.

Research Products

• [Int'l Joint Research] ザンビア大学獣医学部/Central Veterinary Research Institute(ザンビア)
• [Int'l Joint Research] ザンビア大学獣医学部/Central Veterinary Research Institute(ザンビア)
• [Int'l Joint Research] ザンビア大学獣医学部/Central Veterinary Research Institute(ザンビア)
• [Journal Article] Characterization of a Novel Bat Adenovirus Isolated from Straw-Colored Fruit Bat (Eidolon helvum) (2017)
  • Author(s): Ogawa Hirohito、Kajihara Masahiro、Nao Naganori、Shigeno Asako、Fujikura Daisuke、Hang’ombe Bernard、Mweene Aaron、Mutemwa Alisheke、Squarre David、Yamada Masao、Higashi Hideaki、Sawa Hirofumi、Takada Ayato
  • Journal Title: Viruses Volume: 9 Issue: 12 Pages: 371-371
  • DOI: 10.3390/v9120371
  • NAID: 120006382305
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Co-circulation of multiple genotypes of African swine fever viruses among domestic pigs in Zambia (2013-2015). (2017)
  • Author(s): Simulundu E, Chambaro HM, Sinkala Y, Kajihara M, Ogawa H, Mori A, Ndebe J, Dautu G, Mataa L, Lubaba CH, Simuntala C, Fandamu P, Simuunza M, Pandey GS, Samui KL, Misinzo G, Takada A, Mweene AS
  • Journal Title: Transbound Emerg Dis Volume: - Issue: 1 Pages: 114-122
  • DOI: 10.1111/tbed.12635
  • Peer Reviewed / Int'l Joint Research
• [Presentation] フィロウイルスの自然宿主は？-ザンビアでオオコウモリを追う－ (2018)
  • Author(s): 小川寛人
  • Organizer: 第233回アフリカ地域研究会
  • Invited
• [Presentation] Seroepidemiological Prevalence of Multiple Species of Filoviruses in Fruit Bats (Eidolon helvum and Rousettus aegyptiacus) in Zambia (2016)
  • Author(s): Kajihara M, Ogawa H, Miyamoto H, Changula K, Qiu Y, Mori A, Yoshida R, Thomas Y, Nakagawa E, Hang’ombe B, Simulundu E, Muleya W, Katampi J, Igarashi M, Moonga L, Ndebe J, Kapila P, Mweene A, Takada A
  • Organizer: 8th International Symposium on Filoviruses
  • Place of Presentation: Antwerp, Belgium
  • Year and Date: 2016-09-12
  • Int'l Joint Research
• [Presentation] ザンビア共和国に飛来するストローオオコウモリ（Eidolon helvum）から分離されたアデノウイルスの性状解析と分子疫学的解析 (2016)
  • Author(s): 小川寛人，梶原将大，直亨則，丸山隼輝，上野恵介，石井秋宏，藤倉大輔，Hang’ombe Bernard, Aaron Mweene, 山田雅夫，東秀明，澤洋文，高田礼人
  • Organizer: 第159回日本獣医学会学術集会
  • Place of Presentation: 藤沢市
  • Year and Date: 2016-09-06