Research for pathogenic and potentially pathogenic viruses in Zambia
Project/Area Number |
15K18778
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Veterinary medical science
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Research Institution | Hokkaido University |
Principal Investigator |
Kajihara Masahiro 北海道大学, 人獣共通感染症リサーチセンター, 特任助教 (70711894)
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 人獣共通感染症 / ウイルス / 出血熱 / マダニ / コウモリ / ザンビア / アフリカ / マールブルグウイルス / フィロウイルス / エボラウイルス / クリミア・コンゴ出血熱 / フレボウイルス / ダニ媒介性ウイルス / ダニ / 新興感染症 / ウイルス性出血熱 |
Outline of Final Research Achievements |
In this study, epidemiological and ecological survey for known and unknown viruses was carried out in Zambia to understand ecology of these viruses and evaluate their risk for public health in the southern African region . During the research period, 2,327 ticks and 919 bats were sampled in Zambia. By genetic screening using RT-PCR, Crimean-Congo hemorrhagic fever virus was detected in Hyalomma ticks. Marburgvirus genome was also detected in cave-dwelling Egyptian fruit bats captured in September 2018. These viruses are known to cause viral hemorrhagic fevers in humans. In addition, tick-borne phleboviruses were also detected. Phylogenetic analysis revealed that these tick-borne phleboviruses were grouped into 8 distinct clusters including most likely novel genetic lineages. Bat mumpsvirus in the family Paramyxoviridae was also isolated from an Epomophorus sp. bat.
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Academic Significance and Societal Importance of the Research Achievements |
本研究で検出されたCCHFVおよびマールブルグウイルスは共にヒトに対して致死的な出血熱を引き起こすことで知られている。過去、ザンビアにおいてこれらのウイルスによる感染症が発生したことはなく、その存在を示す研究データも存在しなかった。本研究を通して、ザンビアにもこれらの出血熱ウイルスが存在することが初めて示唆された。本研究の成果は同国のみならず、南部アフリカ地域における公衆衛生において非常に重要な知見を提供するものである。
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Report
(5 results)
Research Products
(50 results)
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[Journal Article] Diversity of spotted fever group rickettsiae and their association with host ticks in Japan2019
Author(s)
Thu MJ, Qiu Y, Matsuno K, Kajihara M, Mori-Kajihara A, Omori R, Monma N, Chiba K, Seto J, Gokuden M, Andoh M, Oosako H, Katakura K, Takada A, Sugimoto C, Isoda N, Nakao R
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Journal Title
Scientific Reports
Volume: 9(1)
Issue: 1
Pages: 1500-1500
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Seroprevalence of Filovirus Infection of Rousettus aegyptiacus Bats in Zambia2018
Author(s)
Changula K, Kajihara M, Mori-Kajihara A, Eto Y, Miyamoto H, Yoshida R, Shigeno A, Hang'ombe B, Qiu Y, Mwizabi D, Squarre D, Ndebe J, Ogawa H, Harima H, Simulundu E, Moonga L, Kapila P, Furuyama W, Kondoh T, Sato M, Takadate Y, Kaneko C, Nakao R, Mukonka V, Mweene A, Takada A
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Journal Title
J Infect Dis
Volume: 218(Suppl 5)
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Co-circulation of multiple genotypes of African swine fever viruses among domestic pigs in Zambia (2013-2015).2017
Author(s)
Simulundu E, Chambaro HM, Sinkala Y, Kajihara M, Ogawa H, Mori A, Ndebe J, Dautu G, Mataa L, Lubaba CH, Simuntala C, Fandamu P, Simuunza M, Pandey GS, Samui KL, Misinzo G, Takada A, Mweene AS
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Journal Title
Transbound Emerg Dis
Volume: -
Issue: 1
Pages: 114-122
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Genetic predisposition to acquire a polybasic cleavage site for highly pathogenic avian influenza virus hemagglutinin2017
Author(s)
Nao N, Yamagishi J, Miyamoto H, Igarashi M, Manzoor R, Ohnuma A, Tsuda Y, Furuyama W, Shigeno A, Kajihara M, Kishida N, Yoshida R, Takada A
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Journal Title
MBio
Volume: 8
Issue: 1
Pages: 1-15
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical and subclinical bovine leukemia virus infection in a dairy cattle herd in Zambia2017
Author(s)
Pandey GS, Simulundu E, Mwiinga D, Samui KL, Mweene AS, Kajihara M, Mangani A, Mwenda R, Ndebe J, Konnai S, Takada A.
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Journal Title
Arch Virol.
Volume: 162(4)
Issue: 4
Pages: 1051-1056
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Putative RNA viral sequences detected in an Ixodes scapularis-derived cell line.2016
Author(s)
Nakao R, Matsuno K, Qiu Y, Maruyama J, Eguchi N, Nao N, Kajihara M, Yoshii K, Sawa H, Takada A, Sugimoto C.
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Journal Title
Ticks Tick Borne Dis.
Volume: 8
Issue: 1
Pages: 103-111
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Development of an Immunochromatography Assay (QuickNavi-Ebola) to Detect Multiple Species of Ebolaviruses2016
Author(s)
Yoshida R, Muramatsu S, Akita H, Saito Y, Kuwahara M, Kato D, Changula K, Miyamoto H, Kajihara M, Manzoor R, Furuyama W, Marzi A, Feldmann H, Mweene A, Masumu J, Kapeteshi J, Muyembe-Tamfum JJ, Takada A
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Journal Title
The Journal of Infectious Diseases
Volume: 214(suppl 3)
Issue: suppl 3
Pages: S185-S191
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] A Single Amino Acid in the M1 Protein Responsible for the Different Pathogenic Potentials of H5N1 Highly Pathogenic Avian Influenza Virus Strains2015
Author(s)
Nao N, Kajihara M, Manzoor R, Maruyama J, Yoshida R, Muramatsu M, Miyamoto H, Igarashi M, Eguchi N, Sato M, Kondoh T, Okamatsu M, Sakoda Y, Kida H, Takada A
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Journal Title
PLoS One
Volume: 10(9)
Issue: 9
Pages: e0137989-e0137989
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] The Interaction between TIM-1 and NPC1 is important for the cellular entry of Ebola virus2015
Author(s)
Kuroda M, Fujikura D, Nanbo A, Marzi A, Noyori O, Kajihara M, Maruyama J, Matsuno K, Miyamoto H, Yoshida R, Feldmann H, Takada A
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Journal Title
J. Virol.
Volume: 印刷中
Issue: 12
Pages: 6481-6493
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Seroepidemiological prevalence of multiple species of filoviruses in fruit bats (Eidolon helvum) migrating in Africa.2015
Author(s)
Hirohito Ogawa, Hiroko Miyamoto, Eri Nakayama, Reiko Yoshida, Ichiro Nakamura, Hirofumi Sawa, Akihiro Ishii, Yuka Thomas, Emiko Nakagawa, Keita Matsuno, Masahiro Kajihara, Junki Maruyama, Manabu Igarashi, Kimihito Ito, Ayato Takada et al
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Journal Title
Journal of Infectious Diseases
Volume: jiv063
Issue: suppl 2
Pages: S101-S108
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Seroprevalence of filovirus infection of Rousettus aegyptiacus bats in Zambia2018
Author(s)
Kajihara M, Changula K, Mori-Kajihara A, Eto Y, Miyamoto H, Yoshida R, Shigeno A, Hang'ombe B M, Qiu Y, Mwizabi D, Squarre D, Ogawa H, Harima H, Simulundu E, Kondoh T, Sato M, Takadate Y, Mukonka V, Mweene A S, Takada A
Organizer
The 66th Annual Meeting of the Japanese Society for Virology
Related Report
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[Presentation] Characterization of a novel bat adenovirus isolated from straw-colored fruit bat (Eidolon helvum)2018
Author(s)
Ogawa H, Kajihara M, Nao N, Shigeno A, Fujikura D, Hang'ombe B M, Mweene A S, Mutemwa A, Squarre D, Yamada M, Higashi H, Sawa H, Takada A
Organizer
The 66th Annual Meeting of the Japanese Society for Virology
Related Report
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[Presentation] Serological and molecular evidence for Crimean-Congo hemorrhagic fever virus circulation in ticks, cattle, and humans in Zambia2018
Author(s)
Kajihara M, Simuunza M, Mori-Kajihara A, Saasa N, Qiu Y, Eto Y, Nakao R, Dautu G, Hang'ombe B, Orba Y, Sawa H, Fukushi S, Morikawa S, Saijo M, Arikawa J, Mweene A, Monze M, Mukonka V, Takada A, Yoshimatsu K
Organizer
2018 Negative Strand RNA Virus Meeting
Related Report
Int'l Joint Research
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[Presentation] Surveillance of Viral Zoonoses in Africa2017
Author(s)
Takada A、Kajihara M、Mori A、Yoshida R、Miyamoto H、Igarashi M、Sawa H、Orba Y、Nakamura I、Isoda N、Ishii A、Ito K、Arikawa J、Yoshimatsu K、Ogawa H、Simulundu E、Changula K、Saasa N、Muleya W、Yabe J、Munyeme M、Hang'ombe B、Simuunza M、Choongo K、Mweene A
Organizer
The 2nd International Joint Symposium: Promotion of Infectious Disease Research Cooperation between Africa and Japan toward Science, Technology and Innovation
Related Report
Int'l Joint Research / Invited
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[Presentation] Genetic diversity of rabies virus circulating in different hosts and regions in Zambia and Zimbabwe2016
Author(s)
Muleya W, Chambaro H, Kajihara M, Saasa N, Mori A, Qiu Y, Sasaki M, Gwenhure L, Mweene A, Namangala B, Takada A, Sawa H
Organizer
第64回日本ウイルス学会学術集会
Place of Presentation
札幌コンベンションセンター (北海道・札幌市)
Year and Date
2016-10-23
Related Report
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[Presentation] Involvement of multiple genotypes of African swine fever viruses during 2013-2015 outbreaks in Zambia2016
Author(s)
Simulundu E, Chambaro H, Kajihara M, Ogawa H, Mori A, Ndebe J, Mataa L, Lubaba C, Simuntala C, Dautu G, Misinzo G, Takada A, Mweene A
Organizer
第64回日本ウイルス学会学術集会
Place of Presentation
札幌コンベンションセンター (北海道・札幌市)
Year and Date
2016-10-23
Related Report
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[Presentation] Genetic predisposition to acquire a polybasic cleavage site for highly pathogenic avian influenza virus hemagglutinin/インフルエンザウイルスヘマグルチニン開裂部位への塩基性アミノ酸挿入のメカニズム解析2016
Author(s)
Nao N, Yamagishi J, Miyamoto H, Igarashi M, Manzoor R, Ohnuma A, Tsuda Y, Furuyama W, Kajihara M, Yoshida R, Takada A
Organizer
第64回日本ウイルス学会学術集会
Place of Presentation
札幌コンベンションセンター (北海道・札幌市)
Year and Date
2016-10-23
Related Report
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[Presentation] Seroepidemiological Prevalence of Multiple Species of Filoviruses in Fruit Bats (Eidolon helvum and Rousettus aegyptiacus) in Zambia2016
Author(s)
Kajihara M, Ogawa H, Miyamoto H, Changula K, Qiu Y, Mori A, Yoshida R, Thomas Y, Nakagawa E, Hang’ombe B, Simulundu E, Muleya W, Katampi J, Igarashi M, Moonga L, Ndebe J, Kapila P, Mweene A, Takada A
Organizer
8th International Symposium on Filoviruses
Place of Presentation
Institute of Tropical Medicine (Antwerp, Belgium)
Year and Date
2016-09-12
Related Report
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[Presentation] Genetic divergence of phleboviruses newly identified in ticks collected in Japan, Zambia and the United States/日本国内外のマダニにみられるフレボウイルスの遺伝的多様性2015
Author(s)
Matsuno K, Shimoda H, Torii S, Yongjin Q, Brandi W, Nakao R, Kajihara M, Okamatsu M, Sakoda Y, Okumura A, Takada A, Tom S, Maeda K, Ebihara H.
Organizer
第63回日本ウイルス学会学術集会
Place of Presentation
福岡国際会議場(福岡県・福岡市)
Year and Date
2015-11-22
Related Report
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