Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Outline of Final Research Achievements |
To study the mechanism causing the species difference in analgesic effects of opioid in dogs and cats, we investigated the localization of brain function activated by the nociceptive stimuli and the effects of opioid on the brain function using functional magnetic resonance imaging. In dogs and cats, somatosensory cortex, parietal association cortex, cingulate cortex and cerebellum were significantly activated by the nociceptive stimuli. Further, amygdala, thalamus, and midbrain were activated in dogs and hippocampus was activated in cats. Opioid suppressed the activation of somatosensory cortex in dogs and cats. Opioid also suppressed the activation of amygdala in dogs and cingulate cortex, hippocampus, thalamus, midbrain and cerebellum in cats. This study suggests that opioid suppresses the perception of pain in the brain in both dogs and cats. However, the mechanism causing the species difference of opioid in the blocking autonomic responses to pain in dogs and cats is not revealed.
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