Research Project
Grant-in-Aid for Young Scientists (B)
Fascin-1 is a 54 kDa actin-binding protein and plays an important role in regulating cell adhesion as well as coordinating cell motility and invasion in physiological and pathogenic condition. Canine Fibrosarcoma is a malignant mesenchymal tumor and very locally invasive which often recurs following surgery. It is assumed that recurrence has relation with Fascin-1. Strong Fascin-1 protein expression has revealed in canine fibrosarcoma by immunohistochemistly. Furthermore, a suppressive tendency on cell migration in canine fibrosarcoma cell line by suppressing Fascin-1 was detected.Fascin-1 targeted therapy may represent a new strategy for the canine fibrosarcoma treatment.
