Basic and clinical studies on the renal effects of the alpha 2-adrenoceptor agonist
| Project/Area Number |
15K18794
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | α2アドレナリン受容体 / 腎臓 / デクスメデトミジン / レミフェンタニル / セボフルラン / イヌ / α2アドレナリン受容体作動薬 / 吸入麻酔薬 / 最小肺胞内濃度 |
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| Outline of Final Research Achievements |
The alpha-2 adrenoceptor agonist dexmedetomidine decreased minimum alveolar concentration of sevoflurane in a dose-dependent manner, and there was a synergistic interaction between dexmedetomidine and remifentanil in dogs.
This study revealed that the renal blood flow and glomerular filtration rate were maintained during dexmedetomidine constant rate infusion with sevoflurane-remifentanil anesthesia in dogs, in spite of the heart rate and cardiac index decreased due to the increase of the systemic vascular resistance index.
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Report
(4 results)
Research Products
(2 results)
