Basic and clinical studies on the renal effects of the alpha 2-adrenoceptor agonist

Research Project

Project/Area Number	15K18794
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Veterinary medical science
Research Institution	Tottori University
Principal Investigator	MURAHATA YUSUKE 鳥取大学, 農学部, 助教 (30734743)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	α2アドレナリン受容体 / 腎臓 / デクスメデトミジン / レミフェンタニル / セボフルラン / イヌ / α2アドレナリン受容体作動薬 / 吸入麻酔薬 / 最小肺胞内濃度
Outline of Final Research Achievements	The alpha-2 adrenoceptor agonist dexmedetomidine decreased minimum alveolar concentration of sevoflurane in a dose-dependent manner, and there was a synergistic interaction between dexmedetomidine and remifentanil in dogs. This study revealed that the renal blood flow and glomerular filtration rate were maintained during dexmedetomidine constant rate infusion with sevoflurane-remifentanil anesthesia in dogs, in spite of the heart rate and cardiac index decreased due to the increase of the systemic vascular resistance index.