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Research for genetic and epigenetic mechanism related to radiosensitivity.

Research Project

Project/Area Number 15K18797
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Veterinary medical science
Research InstitutionNippon Veterinary and Life Science University

Principal Investigator

Fujiwara Aki  日本獣医生命科学大学, 獣医学部, 講師 (40709755)

Research Collaborator WATANABE Manabu  東京大学, 新領域創成科学研究科, 准教授
TOMIYASU Hirotaka  東京大学, 大学院農学生命科学研究科, 助教
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords猫リンパ腫 / 放射線療法 / 化学療法 / 鼻腔型リンパ腫 / 放射線抵抗性 / 化学療法抵抗性 / リンパ腫 / 猫 / 放射線
Outline of Final Research Achievements

The prognosis of feline nasal lymphoma is divided into 2 groups; long-survival group after treatment and short-survival group dying within 1 year after treatment. Therefore, the purpose of this research was to explore some factors related to radiosensitivity and chemosensitivity in feline lymphoma.
The one cell line was revealed to be resistant to radiation and one chemotherapeutic agent and expression of some genes which were considered to be sensitivity for radiation and chemotherapy altered compared to that in other cell lines which were sensitive for radiation and chemotherapy. As compared to tumor tissues obtained from cats belonging to long-survival group and short-survival group, the 19 genes were determined to alter their expression.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Products Report
  • Research Products

    (14 results)

All 2021 2019 2018 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (2 results)

  • [Journal Article] Efficacy of chemotherapy and palliative hypofractionated radiotherapy for cats with nasal lymphoma2021

    • Author(s)
      NAKAZAWA Maho、TOMIYASU Hirotaka、SUZUKI Kanako、ASADA Hajime、FUJIWARA-IGARASHI Aki、GOTO-KOSHINO Yuko、OHMI Aki、OHNO Koichi、FUJITA Michio、TSUJIMOTO Hajime
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 83 Issue: 3 Pages: 456-460

    • DOI

      10.1292/jvms.20-0464

    • NAID

      130008021215

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamic pharyngeal collapse in three cats with different pharyngeal pathology2019

    • Author(s)
      FUJIWARA-IGARASHI Aki、YU Yoshihiko、HAMAMOTO Yuji、HASEGAWA Daisuke、FUJITA Michio
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 81 Issue: 7 Pages: 1012-1016

    • DOI

      10.1292/jvms.18-0192

    • NAID

      130007680249

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      Products Report
    • Peer Reviewed / Open Access
  • [Journal Article] 鼻腔・副鼻腔の腫瘍2017

    • Author(s)
      藤原亜紀
    • Journal Title

      SA Medicine

      Volume: 24 Pages: 52-59

    • Related Report
      2017 Annual Research Report
  • [Journal Article] 放射線治療の使いどころ~どんなときに大学に紹介する?~2016

    • Author(s)
      藤原亜紀
    • Journal Title

      CAP

      Volume: 6 Pages: 56-61

    • Related Report
      2016 Research-status Report
  • [Journal Article] 猫の鼻腔内リンパ腫の治療アプローチ2015

    • Author(s)
      藤原亜紀
    • Journal Title

      CAP

      Volume: 10 Pages: 38-45

    • Related Report
      2015 Research-status Report
  • [Journal Article] 化学療法を再考する2015

    • Author(s)
      藤原亜紀
    • Journal Title

      Oncology

      Volume: 7 Pages: 44-49

    • Related Report
      2015 Research-status Report
  • [Presentation] 猫の鼻腔内リンパ腫56症例における治療法と予後に関する回顧的研究2018

    • Author(s)
      鈴木佳奈子、富安博隆、藤原亜紀、後藤裕子、大参亜紀、大野耕一、藤田道郎、辻本元
    • Organizer
      第14回日本獣医内科学アカデミー学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 放射線治療アップデート~これまでの国内治療成績~2017

    • Author(s)
      藤原亜紀
    • Organizer
      第13回日本獣医内科学アカデミー
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2017-02-17
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 日本獣医生命科学大学における放射線治療の現状2017

    • Author(s)
      藤原亜紀
    • Organizer
      第16回日本獣医がん学会
    • Place of Presentation
      ホテルニューオータニ大阪(大阪府大阪市)
    • Year and Date
      2017-01-28
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 動物看護師が知っておくべき放射線治療2016

    • Author(s)
      藤原亜紀
    • Organizer
      第18回日本臨床獣医学フォーラム2016
    • Place of Presentation
      ホテルニューオータニ東京(東京都千代田区)
    • Year and Date
      2016-09-23
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 猫のくしゃみ・逆くしゃみの正体は!?(2)治療編2016

    • Author(s)
      藤原亜紀
    • Organizer
      第12回日本獣医内科学アカデミー
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-02-19
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Evaluation of minimal residual disease in peripheral blood by using the real-time polymerase chain reaction in feline high-grade nasal lymphoma2015

    • Author(s)
      Aki Fujiwara-Igarashi
    • Organizer
      Asian Meetimg of Animal Medicine Specialties
    • Place of Presentation
      Renaissance Kuala Lumpur Hotel (Kuala Lumpur, Malaysia)
    • Year and Date
      2015-11-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 猫の診療指針(鼻炎・鼻腔内腫瘍)2017

    • Author(s)
      藤原亜紀
    • Total Pages
      403
    • Publisher
      緑書房
    • ISBN
      9784895313100
    • Related Report
      2017 Annual Research Report
  • [Book] 犬と猫の治療ガイド2015私はこうしている2015

    • Author(s)
      辻本元、小山秀一、大草潔、兼島孝 (共著)
    • Total Pages
      1119
    • Publisher
      インターズー
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2022-04-15  

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