| Project/Area Number |
15K18798
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Veterinary medical science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
Tamura Kyoichi 日本獣医生命科学大学, 獣医学部, 助教 (00722282)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 犬 / 悪性黒色腫 / 免疫抑制 / DC-HIL |
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| Outline of Final Research Achievements |
Our aim of this project is the establishment of new immunotherapy targeting novel co-inhibitory molecule DC-HIL against canine malignant melanoma. DC-HIL expressed by malignant melanoma cells acted in an inhibitory manner in the tumor immune reaction and showed that tumor growth was promoted. In a case of canine malignant melanoma, we found that DC-HIL in which tumor cells are expressed is involved in the immunosuppression of tumor-bearing individuals and that the prognosis may be poor. In addition, we revealed that anti-dog DC-HIL antibody can inhibit immunosuppressive function by DC-HIL expressed by canine malignant melanoma cells.
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