The central mechanism of hypothermia under infectious stress condition.

• Project/Area Number: 15K18800
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Integrative animal science
• Research Institution: The University of Tokyo
• Principal Investigator: Matsuwaki Takashi 東京大学, 大学院農学生命科学研究科(農学部), 助教 (20447361)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 脳・神経 / プロスタグランジンE2 / 体温低下 / 発熱 / IL-1 / 感染 / mPGES-1 / IL-1 beta / LPS

Outline of Final Research Achievements

We used the transgenic mice lacking the gene for synthase of prostaglandin E2 to evaluate the possible hypothermic center in the central nervous system. We have demonstrated that the hypothermic center is estrogen-responsible activated by immune challenge simultaneously with the hyperthermic center. We have also shown that interleukin-1 type 1 receptor expressed on brain endothelial cells contributes to the febrile response to immune challenge by using tissue specific IL-1R1 KO mice.

Research Products

• [Int'l Joint Research] リンショーピン大学(スウェーデン)