Research Project
Grant-in-Aid for Young Scientists (B)
We used the transgenic mice lacking the gene for synthase of prostaglandin E2 to evaluate the possible hypothermic center in the central nervous system. We have demonstrated that the hypothermic center is estrogen-responsible activated by immune challenge simultaneously with the hyperthermic center. We have also shown that interleukin-1 type 1 receptor expressed on brain endothelial cells contributes to the febrile response to immune challenge by using tissue specific IL-1R1 KO mice.
All Other
All Int'l Joint Research (1 results)
