| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We searched the origin of pituitary stem/progenitor cells present only in the adult and analyzed the differentiation potential into the hormone-producing cells of anterior pituitary. Experiments using mice capable of tracking neural crest cells demonstrated that some of the stem/progenitor cells and hormone-producing cells present in the adult pituitary gland originated from the neural crest. In addition, we revealed that cell clusters isolated from rat pituitary capable of fluorescently labeling S100β expressing cells, which were not present in fetal pituitary, and cell line Tpit/F1 of candidate pituitary stem/progenitor cell possess the stemness and differentiate into hormone-producing cells. These results indicate that stem cells not originating from the oral ectoderm are present in the adult, and that these stem cells are also a source of hormone-producing cells.
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