Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Outline of Final Research Achievements |
Green tea polyphenol Epigallocatechin-3-O-gallate has anti-cancer effect. Several clinical trials show its anti-cancer effect, however, little is known its mechanisms. We previously reported that cGMP mediates anti-cancer effect of EGCG.Because EGCG also have strong suppressing effect on cancer stem cell properties, we hypothesized that cGMP itself has strong inhibitory effect on cancer stem cell properties. Our data shows some kind of cGMP inducer shows strong inhibitory effect on cancer stem cell properties.
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