Screening of the novel target for cancer therapy based on the mechanisms of natural compounds
Project/Area Number |
15K18821
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied molecular and cellular biology
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Research Institution | National Cardiovascular Center Research Institute (2017) Kyushu University (2015-2016) |
Principal Investigator |
Kumazoe Motofumi 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 (70737212)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | cGMP / Caner / EGCG / PDE3 / FOXO3 / がん / 天然物 / がん幹細胞 / 67LR / ケミカルバイオロジー / 抗がん作用 |
Outline of Final Research Achievements |
Green tea polyphenol Epigallocatechin-3-O-gallate has anti-cancer effect. Several clinical trials show its anti-cancer effect, however, little is known its mechanisms. We previously reported that cGMP mediates anti-cancer effect of EGCG.Because EGCG also have strong suppressing effect on cancer stem cell properties, we hypothesized that cGMP itself has strong inhibitory effect on cancer stem cell properties. Our data shows some kind of cGMP inducer shows strong inhibitory effect on cancer stem cell properties.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Metabolic Profiling-based Data-mining for an Effective Chemical Combination to Induce Apoptosis of Cancer Cells.2015
Author(s)
Kumazoe M, Fujimura Y, Hidaka S, Kim Y, Murayama K, Takai M, Huang Y, Yamashita S, Murata M, Miura D, Wariishi H, Maeda-Yamamoto M, Tachibana H.
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Journal Title
Sci Rep.
Volume: 31
Issue: 1
Pages: 9474-9474
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Vardenafil, a clinically available phosphodiesterase inhibitor, potentiates the killing effect of EGCG on CLL cells.2014
Author(s)
Kumazoe, M., Tsukamoto, S., Lesnick, C., Kay, N. E. Yamada, K., Shanafelt T. D. and Tachibana, H.
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Journal Title
Br. J. Haematol.
Volume: 168
Issue: 4
Pages: 610-613
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant