| Project/Area Number |
15K18822
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
Iwata Yuji 大阪府立大学, 生命環境科学研究科, 助教 (80704965)
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | マイクロRNA / シロイヌナズナ / microRNA |
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| Outline of Final Research Achievements |
MicroRNA (miRNA) is a small non-coding RNA molecule found in eukaryotes that functions in regulation of gene expression by binding to mRNA in a sequence-dependent manner and causing mRNA degradation and/or inhibition of translation. I analyzed the molecular function of SERRATE (SE) protein, which has been shown to play important roles in Arabidopsis miRNA biogenesis. I gained insights into how SE's zinc finger domain, N-terminal domain, and C-terminal domain coordinately function to assist miRNA precursor processing by the RNaseIII family endoribonuclease Dicer-Like 1 (DCL1).
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