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Construction of Anisotropic, Three-Dimensional, and Dynamic Molecular-Assembled Systems of Synthetic Double Helices and Development of Macroscopic Motional Functions

Research Project

Project/Area Number 15K18825
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Chemical pharmacy
Research InstitutionTohoku University

Principal Investigator

SAITO Nozomi  東北大学, 薬学研究科, 助教 (40636411)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsヘリセン / オリゴマー / 二重ラセン / 異方性 / 自己組織化 / 液晶 / 熱応答 / 超長鎖 / トリエチレングリコール / 水和 / 超長鎖アルカン
Outline of Final Research Achievements

Molecular properties of ethynylhelicene oligomers were controlled by taking advantage of molecular design. Then, construction of aniosotropic, three-dimensional, and dynamic molecular-assembled systems was examined by utilizing the self-assembly in order to integrate the molecular-level transition between double helices and random coils to a muscle-like macroscopic motion. (1) With regard to the oligomers which form anisotropic and fluidic thermotropic liquid crystals, reversibility of structural change was improved. (2) Details of the unique thermoresponse of the oligomers with TEG groups were revealed, such as the variety of applicable solvents and the dependence on the solvent composition. (3) A 1,ω-alkanediol with carbon number 128 was synthesized in order to align the oligomers in an anisotropic manner by taking advantage of the crystallinity of the superlong-chain alkane.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (29 results)

All 2017 2016 2015

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Acknowledgement Compliant: 6 results,  Open Access: 5 results) Presentation (20 results) (of which Int'l Joint Research: 4 results,  Invited: 7 results)

  • [Journal Article] Mechanical Stirring Induces Heteroaggregate Formation and Self-assembly of Pseudoenantiomeric Oxymethylene Helicene Oligomers in Solution2017

    • Author(s)
      Tsukasa Sawato, Nozomi Saito, Masanori Shigeno, Masahiko Yamaguchi
    • Journal Title

      ChemistrySelect

      Volume: 2 Issue: 6 Pages: 2205-2211

    • DOI

      10.1002/slct.201700303

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Multiple competing pathways for chemical reaction: drastic reaction shortcut for the self-catalytic double-helix formation of helicene oligomers2017

    • Author(s)
      Yo Kushida, Nozomi Saito, Masanori Shigeno, Masahiko Yamaguchi
    • Journal Title

      Chem. Sci.

      Volume: 8 Issue: 2 Pages: 1414-1421

    • DOI

      10.1039/c6sc01893a

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] エチニルヘリセンオリゴマーの分子設計と合成,会合,自己組織化および液晶形成の制御2017

    • Author(s)
      齋藤 望,山口 雅彦
    • Journal Title

      日本液晶学会誌「液晶」

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deterministic and Stochastic Chiral Symmetry Breaking Exhibited by Racemic Aminomethylenehelicene Oligomers2016

    • Author(s)
      Yo Kushida, Tsukasa Sawato, Masanori Shigeno, Nozomi Saito, Masahiko Yamaguchi
    • Journal Title

      Chem. Eur. J.

      Volume: 23 Issue: 2 Pages: 327-333

    • DOI

      10.1002/chem.201601792

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Spatially Heterogeneous Nature of Self-Catalytic Reaction in Hetero-Double Helix Formation of Helicene Oligomers2016

    • Author(s)
      Yo Kushida, Tsukasa Sawato, Nozomi Saito, Masanori Shigeno, Hiroshi Satozono, Masahiko Yamaguchi
    • Journal Title

      ChemPhysChem

      Volume: 17 Issue: 20 Pages: 3283-3288

    • DOI

      10.1002/cphc.201600627

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Equilibrum and Nonequilibrium Chemical Reactions of Helicene Oligomers in the Noncovalent Bond Formation2016

    • Author(s)
      Masahiko Yamaguchi; Mieko Arisawa; Masanori Shigeno; Nozomi Saito
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 89 Issue: 10 Pages: 1145-1169

    • DOI

      10.1246/bcsj.20160133

    • NAID

      130006770658

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] “ Inverse” thermoresponse: heat-induced double-helix formation of an ethynylhelicene oligomer with tri(ethylene glycol) termini2016

    • Author(s)
      Nozomi Saito, Higashi Kobayashi, Masahiko Yamaguchi
    • Journal Title

      Chemical Science

      Volume: 未定 Issue: 6 Pages: 3574-3580

    • DOI

      10.1039/c5sc04959h

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Dynamic and Reversible Polymorphism of Self-Assembled Lyotropic Liquid Crystalline Systems Derived from Cyclic Bis(ethynylhelicene) Oligomers2015

    • Author(s)
      Nozomi Saito, Kiyoshi Kanie, Masaki Matsubara, Atsushi Muramatsu, and Masahiko Yamaguchi
    • Journal Title

      Journal of the American Chemical Society

      Volume: 137 Issue: 20 Pages: 5601-5607

    • DOI

      10.1021/jacs.5b02003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Structure and Property Diversity of Chiral Helicene Oligomers2015

    • Author(s)
      Nozomi Saito, Masanori Shigeno, Masahiko Yamaguchi
    • Journal Title

      Encyclopedia of Polymer Science and Technology

      Volume: 未定 Pages: 1-32

    • DOI

      10.1002/0471440264.pst643

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 機械的刺激による擬鏡像異性体オキシメチレンヘリセンオリゴマーの構造変化と自己組織化体形成2017

    • Author(s)
      澤藤 司,齋藤 望,山口 雅彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学 川内キャンパス,宮城県仙台市
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] アンチパラレル会合を用いたビス(分岐状オリゴエチニルヘリセン)の分子内・分子間会合制御2017

    • Author(s)
      齋藤 望,近藤 祐太朗,重野 真徳,雨宮 亮,山口 雅彦
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      東北大学 川内キャンパス,宮城県仙台市
    • Year and Date
      2017-03-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] アミノメチレンヘリセンオリゴマー擬鏡像異性体混合物のスイング現象2017

    • Author(s)
      近藤 祐太朗,齋藤 望,山口 雅彦
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶応義塾大学 日吉キャンパス,神奈川県日吉市
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] ラセミ体オキシメチレンヘリセンオリゴマーの機械的刺激応答凝集におけるキラル対称性の破れ2017

    • Author(s)
      澤藤 司,齋藤 望,山口 雅彦
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶応義塾大学 日吉キャンパス,神奈川県日吉市
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] Synthesis, aggregation, anisotropic self-assembly, and control of dynamic properties of optically active ethynylhelicene oligomers2017

    • Author(s)
      SAITO, Nozomi; YAMAGUCHI, Masahiko
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶応義塾大学 日吉キャンパス,神奈川県日吉市
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] トリエチレングリコール部の位置がエチニルヘリセンオリゴマーの水系溶媒中における会合に与える効果2017

    • Author(s)
      齋藤 望,土屋 駿平,山口 雅彦
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶応義塾大学 日吉キャンパス,神奈川県日吉市
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] トリエチレングリコール末端を有するエチニルヘリセンオリゴマーの水系溶媒中逆熱応答における有機溶媒の効果2017

    • Author(s)
      齋藤 望,小林 東史,山口 雅彦”
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶応義塾大学 日吉キャンパス,神奈川県日吉市
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 1,128-アルカンジオールの有機溶媒に対する溶解度の温度依存性2017

    • Author(s)
      篠﨑 康宏,齋藤 望,重野 真徳,山口 雅彦
    • Organizer
      日本化学会第97春季年会
    • Place of Presentation
      慶応義塾大学 日吉キャンパス,神奈川県日吉市
    • Year and Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Presentation] 光学活性エチニルヘリセンオリゴマーの合成と会合および自己組織化2016

    • Author(s)
      齋藤 望
    • Organizer
      有機π電子系学会主催 第10回有機π電子系シンポジウム
    • Place of Presentation
      あうる京北,京都府京都市右京区
    • Year and Date
      2016-12-16
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Synthesis, Structure, and Dynamic Properties of Helicene Oligomers2016

    • Author(s)
      Nozomi Saito, Masahiko Yamaguchi
    • Organizer
      Workshop on Aromatic Foldamers 2016
    • Place of Presentation
      University of Science, Philadelphia, USA
    • Year and Date
      2016-06-20
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] リエチレングリコール末端を有するエチニルヘリセンオリゴマーの逆熱応答と溶媒効果2016

    • Author(s)
      齋藤 望, 小林 東史,山口 雅彦
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      京都府京田辺市同,志社大学京田辺キャンパス
    • Year and Date
      2016-03-24
    • Related Report
      2015 Research-status Report
  • [Presentation] エチニルヘリセンオリゴマー自己組織化によるリオトロピック液晶形成と熱応答2016

    • Author(s)
      齋藤 望,山口 雅彦
    • Organizer
      日本化学会第96春季年会
    • Place of Presentation
      京都府京田辺市同,志社大学京田辺キャンパス
    • Year and Date
      2016-03-24
    • Related Report
      2015 Research-status Report
  • [Presentation] ヘリセンオリゴマーの合成と会合・自己組織化制御および動的機能2016

    • Author(s)
      齋藤 望
    • Organizer
      平成28年度日本薬学会東北支部主催 第38回東北薬学セミナー
    • Place of Presentation
      ホテル仙台ガーデンパレス,宮城県仙台市
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Synthesis, Aggregation, and Self-Assembly of Ethynylhelicene Oligomers2016

    • Author(s)
      Nozomi Saito
    • Organizer
      The 1st International Symposium on Chemical Communication
    • Place of Presentation
      Graduate School of Science and Faculty of Science, Tohoku University, Sendai, Japan
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Synthesis, liquid crystal formation, and double helix-random coil transition in bulk of ethynylhelicene oligomers possessing dendric mesogenic moieties2015

    • Author(s)
      Nozomi Saito, Masahiko Yamaguchi
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (Pacifichem) 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] トリエチレングリコキシ末端を有するエチニルヘリセンオリゴマーの合成と逆熱応答:加熱による二重ラセン形成2015

    • Author(s)
      齋藤 望,小林 東史,山口 雅彦
    • Organizer
      第30回若手研究者の仙台セミナー
    • Place of Presentation
      宮城県仙台市青葉区,東北大学大学院薬学研究科大講義室
    • Year and Date
      2015-12-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 光学活性エチニルヘリセンオリゴマーの合成と会合および液晶形成2015

    • Author(s)
      齋藤 望
    • Organizer
      若手研究者のための有機化学札幌セミナー
    • Place of Presentation
      北海道札幌市,北海道大学 理学部5号館 大講堂
    • Year and Date
      2015-11-23
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] トリエチレングリコキシ末端を有するエチニルヘリセンオリゴマーの二重ラセン形成と 逆熱応答2015

    • Author(s)
      齋藤 望,小林 東史,山口 雅彦
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      大阪府大阪市小若江,近畿大学11月ホール
    • Year and Date
      2015-10-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Synthesis, Aggregation, and Liquid Crystal Formation of Ethynylhelicene Oligomers2015

    • Author(s)
      Nozomi Saito, Masahiko Yamaguchi
    • Organizer
      The 6th Japanese-Sino Symposium on Organic Chemistry for Young Scientists
    • Place of Presentation
      Akiu Resort Hotel Crescent, Sendai, Japan
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] “Double-Helix Formation of an Ethynylhelicene Oligomer with Tri(Ethylene Glycoxy) Termini Induced by Heating2015

    • Author(s)
      Nozomi Saito, Higashi Kobayashi, Masahiko Yamaguchi
    • Organizer
      Organic Chemistry Symposium: Royal Society of Chemistry Roadshow
    • Place of Presentation
      Graduate School of Science and Faculty of Science, Tohoku University, Sendai, Japan
    • Year and Date
      2015-06-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2015-04-16   Modified: 2018-03-22  

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