| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Outline of Final Research Achievements |
NHC ligands are generally equipped with bulky N-substituents, while our bicyclic NHC possess a bulky phenyl ring on the non-carbenic carbons. In this study, we applied our novel NHC ligands to transitional metal catalysts and investigated the effects of the unique steric properties.
The copper complexes supported by our NHCs were stable on a bench and successfully catalyzed the borylation of arylbromide. In this catalysis, the bicyclic NHC ligand showed significantly higher reactivity toward hindered substrates than ubiquitous NHCs, which indicates that the bicyclic NHC is bulky but accessible. On the nickel catalysis, our ligand effectively worked for the Kumada-Tamao-Corriu coupling of arylboromides with tertiary alkyl Grignard reagents. We also developed the stable NHC-Ni precatalyst which finely worked for Suzuki-Miyaura cross-coupling.
|
