| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In this study, ligand-controlled site-selective reactions, which are powerful tools for effective synthesis of multisubstituted compounds, were developed. Dihydroxyterphenylphosphine (DHTP), which was previously developed by our group, was employed as a ligand, and various reactions were screened using a catalyst derived palladium and DHTP. As a result, arylation of nonsubstituted indole with chloroarenes proceeded C3-selectively using Pd-DHTP catalyst. On the other hand, other commercially available ligands used in cross coupling of chloroarenes afforded N-arylated product selectively. In addition, several DHTP analogs were designed as a new ligands and synthesized. These ligand showed different reactivity and site-selectivity from those of DHTP.
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