Efficient synthesis of compounds having various substitution patterns using ligand-controlled site-selective reactions
| Project/Area Number |
15K18833
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | University of Shizuoka |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 触媒 / 位置選択性 / 配位子 / 有機化学 / クロスカップリング |
|---|
| Outline of Final Research Achievements |
In this study, ligand-controlled site-selective reactions, which are powerful tools for effective synthesis of multisubstituted compounds, were developed. Dihydroxyterphenylphosphine (DHTP), which was previously developed by our group, was employed as a ligand, and various reactions were screened using a catalyst derived palladium and DHTP. As a result, arylation of nonsubstituted indole with chloroarenes proceeded C3-selectively using Pd-DHTP catalyst. On the other hand, other commercially available ligands used in cross coupling of chloroarenes afforded N-arylated product selectively. In addition, several DHTP analogs were designed as a new ligands and synthesized. These ligand showed different reactivity and site-selectivity from those of DHTP.
|
Report
(3 results)
Research Products
(13 results)
