| Project/Area Number |
15K18837
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 酸素分子 / 触媒反応 / マンガン錯体 / オキシム / ヒドロキシアミン / 酸化反応 / ジヒドロイソオキサゾール環 / 不斉反応 |
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| Outline of Final Research Achievements |
Developing a new methodology for transition metal-catalyzed oxidation reactions has been extensively studied in the recent decade, and molecular oxygen is essentially recognized as an ideal oxidant. Despite developing several elegant oxidation processes involving molecular oxygen as a sole oxidant, methodologies for directly incorporating molecular oxygen into organic substrates remain a major challenge in synthetic chemistry. Based on such backgrounds, we have found that manganese(III) acetylacetonate is a highly efficient catalyst (generally 0.02-0.5 mol%, and a minimum of 0.001 mol%) for the oxidative cyclization reactions of unsaturated oximes to provide 4,5-dihydroisoxazoline alcohols, and the hydroperoxidation reactions of carbon-carbon double bond of enynes as well as styrene derivatives using N-hydroxyphthalimide, N-hydroxybenzotriazole or N-hydroxysuccinimide through the direct incorporation of molecular oxygen present in air (open flask).
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