Research and development of organocatalyst as an artificial acylating enzyme
| Project/Area Number |
15K18838
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 有機触媒 / 不斉合成 / フルオラス / 有機分子触媒 |
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| Outline of Final Research Achievements |
I constructed an organocatalyst library having various sulfonamide type structures derived from natural amino acids for the purpose of developing an artificial acylating catalyst. The optical resolution reaction of phenylethane-1,2-diol performed as a model reaction did not give good results. Therefore, I studied stereoselective carbon-carbon bond formation reaction using this organocatalyst library. As a result, good results were obtained in asymmetric conjugate addition reaction of α, β-unsaturated ketone and nitroalkane, and direct-vinylogous aldol reaction between γ-crotonolactone and aldehyde.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Design of Novel Hydrogen-Bonding Donor Organocatalysts and their Application to Asymmetric Direct Aldol Reaction2017
Author(s)
H. Akutsu, K. Nakashima, H. Yanai, A. Kotani, S. Hirashima, T. Yamamoto, R. Takahashi, A. Yoshida, Y. Koseki, H. Hakamata, T. Matsumoto, T. Miura,
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Journal Title
Related Report
Peer Reviewed
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