| Project/Area Number |
15K18838
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 有機触媒 / 不斉合成 / フルオラス / 有機分子触媒 |
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| Outline of Final Research Achievements |
I constructed an organocatalyst library having various sulfonamide type structures derived from natural amino acids for the purpose of developing an artificial acylating catalyst. The optical resolution reaction of phenylethane-1,2-diol performed as a model reaction did not give good results. Therefore, I studied stereoselective carbon-carbon bond formation reaction using this organocatalyst library. As a result, good results were obtained in asymmetric conjugate addition reaction of α, β-unsaturated ketone and nitroalkane, and direct-vinylogous aldol reaction between γ-crotonolactone and aldehyde.
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