| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The cyclic skeleton is a component included in many biologically active compounds, and the development of a novel methodology for construction of cyclic skeletons is an important research topic leading to the creation of medicines, agricultural chemicals and the like. In this research, we aimed to develop a new method for the synthesis of carbocycles using N-heterocyclic carbene (NHC)-catalyzed umpolung-type γ addition reaction. As a result of various investigations, the γ addition reaction promoted by the addition of NHC proceeded and succeeded in the synthesis of the multiply substituted cyclopentene derivative. We also found that various indole derivatives can be synthesized by using halogen bond donating type iodine catalyst induced by iodination of NHC in the process of this investigation.
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