Analysis of host-microbe interction in the gut of Drsoophila melanogaster
| Project/Area Number |
15K18855
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Kanazawa University (2016)
Keio University (2015) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腸内細菌 / 腸管免疫 |
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| Outline of Final Research Achievements |
The intestinal tract is one of the first organs acquired by multicellular organisms in the course of evolution. Because of its essential role in the digestion and absorption of food, its nutritive environment provides an ideal niche for commensal microbes, the effects of which are considered tremendous on hosts. Drosophila melanogaster, an invertebrate model organism, certainly possesses a gut, and its microbes could be used for investigating host-microbe interactions. However, generating and maintaining “germ-free” Drosophila is rather challenging. In this study, we established a solid and perhaps the first method for establishing germ-free flies, using a vinyl isolator and fly food with a specific composition. This germ-free fly technique could provide a pivotal basis for analyzing gnotobiotic Drosophila, which will improve our understanding of evolutionarily conserved host-microbe interactions in the intestine.
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Report
(3 results)
Research Products
(12 results)
