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Functional analysis of novel phosphoinositide metabolites

Research Project

Project/Area Number 15K18857
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionAkita University

Principal Investigator

Nakanishi Hiroki  秋田大学, 生体情報研究センター, 助教 (10466740)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords質量分析 / リピドミクス / ホスホイノシタイド / 生理活性 / イノシトールリン脂質 / 新規リン脂質 / 質量分析法 / 同定
Outline of Final Research Achievements

Phosphoinositide (PIP) is a membrane phospholipid composed of diacylglycerol and a D-myo-inositol head group. In mammals, the hydroxyl groups at the D3, D4 and D5 positions of the inositol ring can be phosphorylated to yield seven phosphoinositide derivatives. Recently, we developed high sensitivity PIPs detection method using LC-MS/MS system. Additionally, in the process of detecting PIPs in various biological samples, we found lysoPIPs which is detected at high levels in mouse cancer tissue. The aim of this study is to elucidate the physiological functions of PIPs and novel lysoPIPs and the pathological mechanism caused by PIPs metabolic abnormality. Future work, we aim to establish non-invasive biomarkers using blood sample. The development of novel biomarkers using phosphoinositide profiling is a world's first and an epoch-making attempt.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015 Other

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results,  Acknowledgement Compliant: 3 results) Book (1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Decreased 16:0/20:4-phosphatidylinositol level in the post-mortem prefrontal cortex of elderly patients with schizophrenia.2017

    • Author(s)
      Matsumoto J, Nakanishi H, Kunii Y, Sugiura Y, Yuki D, Wada A, Hino M, Niwa SI, Kondo T, Waki M, Hayasaka T, Masaki N, Akatsu H, Hashizume Y, Yamamoto S, Sato S, Sasaki T, Setou M, Yabe H.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 7 Pages: 45050-45050

    • DOI

      10.1038/srep45050

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy.2017

    • Author(s)
      Kimura H, Eguchi S, Sasaki J, Kuba K, Nakanishi H, Takasuga S, Yamazaki M, Goto A, Watanabe H, Itoh H, Imai Y, Suzuki A, Mizushima N, Sasaki T
    • Journal Title

      JCI Insight

      Volume: 2 Issue: 1 Pages: 89462-89478

    • DOI

      10.1172/jci.insight.89462

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Histone deacetylase inhibitors inhibit metastasis by restoring a tumor suppressive microRNA-150 in advanced cutaneous T-cell lymphoma.2017

    • Author(s)
      Abe F, Kitadate A, Ikeda S, Yamashita J, Nakanishi H, Takahashi N, Asaka C, Teshima K, Miyagaki T, Sugaya M, Tagawa H.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 5 Pages: 7572-7585

    • DOI

      10.18632/oncotarget.13810

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] INPP4B is a PtdIns(3,4,5)P3 phosphatase that can act as a tumor suppressor.2015

    • Author(s)
      Kofuji S, Kimura H, Nakanishi H, Nanjo H, Takasuga S, Liu H, Eguchi S, Nakamura R, Itoh R, Ueno N, Asanuma K, Huang M, Koizumi A, Habuchi T, Yamazaki M, Suzuki A, Sasaki J, Sasaki T
    • Journal Title

      Cancer Discovery

      Volume: in press Issue: 7 Pages: 730-9

    • DOI

      10.1158/2159-8290.cd-14-1329

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of group IIF secreted phospholipase A2 in epidermal homeostasis and hyperplasia.2015

    • Author(s)
      Yamamoto, K., Miki, Y., Sato, M., Taketomi, Y., Nishito, Y., Taya, C., Muramatsu, K., Ikeda, K., Nakanishi, H., Taguchi, R., Kambe, N., Kabashima, K., Lambeau, G., Gelb, M.H., and Murakami, M
    • Journal Title

      J. Exp. Med.

      Volume: 212 Issue: 11 Pages: 1901-1919

    • DOI

      10.1084/jem.20141904

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] ホスホイノシタイドミクス-代謝異常と病態-2015

    • Author(s)
      中西広樹
    • Journal Title

      実験医学増刊

      Volume: 33 Pages: 206-210

    • Related Report
      2015 Research-status Report
  • [Book] 生体の科学2016

    • Author(s)
      中西広樹
    • Total Pages
      5
    • Publisher
      医学書院
    • Related Report
      2016 Annual Research Report
  • [Remarks] 秋田大学生体情報研究センター

    • URL

      http://www.gipc.akita-u.ac.jp/~arcbs/index.html

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
  • [Patent(Industrial Property Rights)] ホスホイノシタイド分離測定法の開発2017

    • Inventor(s)
      中西広樹. 佐々木雄彦. 佐々木純子. 江口賢史. 中西貴代.
    • Industrial Property Rights Holder
      秋田大学, ALTe
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-051354
    • Filing Date
      2017-03-16
    • Related Report
      2016 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規リン脂質およびその利用.2016

    • Inventor(s)
      佐々木雄彦. 中西広樹. 江口賢史. 佐々木純子.
    • Industrial Property Rights Holder
      秋田大学, ALTe
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-144177
    • Filing Date
      2016-07-22
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-12-17  

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