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The role of protein arginine methyltransferase (PRMT) in brain tumor

Research Project

Project/Area Number 15K18858
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biological pharmacy
Research InstitutionNagoya City University

Principal Investigator

Hiyoshi Hiromi  名古屋市立大学, 大学院医学研究科, 助教 (10406530)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords脳腫瘍 / アルギニンメチル化酵素 / 細胞周期
Outline of Final Research Achievements

It is known that the protein arginine methyltransferase (PRMT) 8 is a brain-specific member of the PRMT family. But, PRMT8 was not detected in glioma cell lines. We tried to over-express of PRMT8 in glioma cells. Over-expression of PRMT8 suppressed cell proliferation in glioma cell lines. There was no change in arginine methylation of protein, although it is the main action of PRMT family. Therefore, we investigated the expression of protein involved cancer cell proliferation. The level of Rb protein, key factor of cell cycle, was decreased in glioma cells over-expressed with PRMT8. These results suggest that PRMT8 inhibits the cell proliferation of brain tumor by novel mechanism.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 2014

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin beta1 in endothelial cells.2017

    • Author(s)
      Maekawa M, Tanigawa K, Sakaue T, Hiyoshi H, Kubota E, Joh T, Watanabe Y, Taguchi T, Higashiyama S
    • Journal Title

      Biolology Open

      Volume: 6 Pages: 1707-1719

    • DOI

      10.1242/bio.029579

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function.2017

    • Author(s)
      Sakaue T, Fujisaki A, Nakayama H, Maekawa M, Hiyoshi H, Kubota E, Joh T, Izutani H, Higashiyama S.
    • Journal Title

      Cancer Sci.

      Volume: 108 Issue: 2 Pages: 208-215

    • DOI

      10.1111/cas.13133

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prognostic significance of immunohistochemical expression of the ubiquitin ligase carboxyl terminus of Hsc70-interacting protein (CHIP) in postmenopausal women with invasive breast cancer2016

    • Author(s)
      Kurozumi S, Yamaguchi Y, Hayashi S, Hiyoshi H, Suda T, Matsumoto H, Takei H, Horiguchi J, Oyama T, Takeyoshi I, Kurosumi M
    • Journal Title

      Cancer Med

      Volume: 5(8) Issue: 8 Pages: 1873-1882

    • DOI

      10.1002/cam4.780

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CHIP acts as a capacitor of phenotypic heterogeneity in breast cancer cells2014

    • Author(s)
      Tsuchiya M, Nakajima Y, Waku T, Hiyoshi H, Morishita T, Furumai R, Hayashi Y, Kishimoto H, Kimura K, Yanagisawa J.
    • Journal Title

      Oncogene

      Volume: なし Issue: 35 Pages: 1-8

    • DOI

      10.1038/onc.2014.387

    • Related Report
      2015 Research-status Report
    • Peer Reviewed

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Published: 2015-04-16   Modified: 2019-03-29  

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