| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
It is known that the protein arginine methyltransferase (PRMT) 8 is a brain-specific member of the PRMT family. But, PRMT8 was not detected in glioma cell lines. We tried to over-express of PRMT8 in glioma cells. Over-expression of PRMT8 suppressed cell proliferation in glioma cell lines. There was no change in arginine methylation of protein, although it is the main action of PRMT family. Therefore, we investigated the expression of protein involved cancer cell proliferation. The level of Rb protein, key factor of cell cycle, was decreased in glioma cells over-expressed with PRMT8. These results suggest that PRMT8 inhibits the cell proliferation of brain tumor by novel mechanism.
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