Elucidation of a prostanoid receptor CRTH2-related mechanism in the regulation of higher brain functions

• Project/Area Number: 15K18874
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pharmacology in pharmacy
• Research Institution: Setsunan University (2016); Osaka University (2015)
• Principal Investigator: Onaka Yusuke 摂南大学, 薬学部, 助教 (90749003)
• Project Period (FY): 2015-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: PGD2 / 情動機能 / 認知機能 / 炎症 / 統合失調症 / がん / 薬学 / 脳・神経 / 薬理学 / 生理活性 / プロスタグランジンD2 / CRTH2 / モノアシルグリセロールリパーゼ / 扁桃体 / 前頭前皮質 / 情動機能障害 / 認知機能障害

Outline of Final Research Achievements

Prostaglandin D2 receptor, CRTH2, has well studied in the field of peripheral inflammation. Recently, it has revealed that CRTH2 functions in the emotional and cognitive impairments. In this study, it was shown that CRTH2 signaling in the local brain area could regulate the local neural function, and that CRTH2 signaling alternates local neural function related to the cognitive dysfunction, by using pathological animal models. These findings would contribute to understand the detailed role of CRTH2 in emotional and cognitive dysfunctions in pathological states.

Research Products

• [Journal Article] Improvement by methylphenidate and atomoxetine of social interaction deficits and recognition memory impairment in a mouse model of valproic acid-induced autism (2016)
  • Author(s): Hara Y, Ago Y, Taruta A, Katashiba K, Hasebe S, Takano E, Onaka Y, Hashimoto H, Matsuda T, Takuma K
  • Journal Title: Autism Research Volume: - Issue: 9 Pages: 926-939
  • DOI: 10.1002/aur.1596
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prenatal Exposure to Histone Deacetylase Inhibitors Affects Gene Expression of Autism-Related Molecules and Delays Neuronal Maturation (2016)
  • Author(s): Kawanai T, Ago Y, Watanabe R, Inoue A, Taruta A, Onaka Y, Hasebe S, Hashimoto H, Matsuda T, Takuma K.
  • Journal Title: Neurochem. Res. Volume: 41(10) Issue: 10 Pages: 2574-2584
  • DOI: 10.1007/s11064-016-1969-y
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Involvement of GABAA receptors in 5-HT1A and σ1 receptor synergism on prefrontal dopaminergic transmission under circulating neurosteroid deficiency (2016)
  • Author(s): Ago Y, Hasebe S, Hiramatsu N, Mori K, Watabe Y, Onaka Y, Hashimoto H, Takuma K, Matsuda T.
  • Journal Title: Psychopharmacology(Berl) Volume: 233(17) Issue: 17 Pages: 3125-3134
  • DOI: 10.1007/s00213-016-4353-3
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Prostaglandin D2 signaling mediated by the CRTH2 receptor is involved in MK-801-induced cognitive dysfunction. (2016)
  • Author(s): Onaka Y, Shintani N, Nakazawa T, Kanoh T, Ago Y, Matsuda T, Hashimoto R, Ohi K, Hirai H, Nagata KY, Nakamura M, Kasai A, Hayata-Takano A, Nagayasu K, Takuma K, Ogawa A, Baba A, Hashimoto H.
  • Journal Title: Behav Brain Res. Volume: 314 Pages: 477-486
  • DOI: 10.1016/j.bbr.2016.07.050
  • Peer Reviewed / Open Access
• [Presentation] 腫瘍の形成に伴って認められる高次脳機能障害は腫瘍切除後も持続する (2017)
  • Author(s): 尾中 勇祐、新谷 紀人、中澤 敬信、吾郷 由希夫、木野村 元彦、田邊 航、荻田 喜代一、橋本 均
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台
  • Year and Date: 2017-03-24
• [Presentation] がん治療後に持続する高次脳機能障害におけるシクロオキシゲナーゼの関与 (2016)
  • Author(s): 尾中 勇祐、新谷 紀人、中澤 敬信、吾郷 由希夫、木野村 元彦、田邊 航、荻田 喜代一、橋本 均
  • Organizer: 第130回日本薬理学会近畿部会
  • Place of Presentation: 京都
• [Presentation] がん治療後の脳機能障害の解明に有用な動物モデルの作製 (2015)
  • Author(s): 尾中 勇祐、木野村 元彦、新谷 紀人、平井 博之、永田 欽也、中村 正孝、長谷部 茂、永安 一樹、吾郷 由希夫、笠井 淳司、早田 敦子、中澤 敬信、田熊 一敞、松田 敏夫、馬場 明道、橋本 均
  • Organizer: 第127回日本薬理学会近畿部会
  • Place of Presentation: 岐阜
  • Year and Date: 2015-06-26