Mechanism underlying upregulation of calcium-sensing receptor in pulmonary hypertension
Project/Area Number |
15K18881
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pharmacology in pharmacy
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Research Institution | Kinjo Gakuin University |
Principal Investigator |
YAMAMURA Aya 金城学院大学, 薬学部, 助教 (40633219)
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Project Period (FY) |
2015-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 肺高血圧症 / カルシウム感受性受容体 / イオンチャネル / 肺動脈 / 平滑筋 / カルシウムシグナル / 細胞増殖 / リモデリング / ホスホジエステラーゼ / 肺高血圧 / TRPC6チャネル |
Outline of Final Research Achievements |
Pulmonary arterial hypertension is an intractable disease that pulmonary arterial pressure chronically increases due to vascular impairment. We found that upregulation of calcium-sensing receptor in pulmonary arterial smooth muscle cells is involved in pathogenesis of pulmonary arterial hypertension. In this study, we showed that functional coupling of calcium-sensing receptor with TRPC6 channel and usefulness of calcium-sensing receptor antagonists for pulmonary arterial hypertension. Our findings provide novel therapeutic strategies for pulmonary arterial hypertension.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH.2017
Author(s)
Song S, Ayon RJ, Yamamura A, Yamamura H, Dash S, Babicheva A, Tang H, Sun X, Cordery AG, Khalpey Z, Black SM, Desai AA, Rischard F, McDermott KM, Garcia JG, Makino A, Yuan JX.
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Journal Title
Am J Physiol Lung Cell Mol Physiol.
Volume: 312(3)
Issue: 3
Pages: L309-L325
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Nicotinamide phosphoribosyltransferase promotes pulmonary vascular remodeling and is a therapeutic target in pulmonary arterial hypertension.2017
Author(s)
Chen J, Sysol JR, Singla S, Zhao S, Yamamura A, Valdez-Jasso D, Abbasi T, Shioura KM, Sahni S, Reddy V, Sridhar A, Gao H, Torres J, Camp SM, Tang H, Ye SQ, Comhair S, Dweik R, Hassoun P, Yuan JX, Garcia JG, Machado RF.
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Journal Title
Circulation
Volume: 135(16)
Issue: 16
Pages: 1532-1546
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension.2016
Author(s)
Tang H, Yamamura A, Yamamura H, Song S, Fraidenburg DR, Chen J, Gu Y, Pohl NM, Zhou T, Jiménez-Pérez L, Ayon RJ, Desai AA, Goltzman D, Rischard F, Khalpey ZI, Black SM, Garcia JG, Makino A, Yuan JX.
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Journal Title
Am J Physiol Lung Cell Mol Physiol.
Volume: in press
Issue: 9
Pages: L846-L859
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Notch Activation of Ca2+ Signaling Mediates Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension2015
Author(s)
Smith KA, Voiriot G, Tang H, Fraidenburg DR, Song S, Yamamura H, Yamamura A, Guo Q, Wan J, Pohl NM, Tauseef M, Bodmer R, Ocorr K, Thistlethwaite PA, Haddad GG, Powell FL, Makino A, Mehta D, Yuan JX
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Journal Title
Am J Respir Cell Mol Biol
Volume: in press
Issue: 3
Pages: 355-367
DOI
Related Report
Peer Reviewed
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[Presentation] Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) attenuated experimental pulmonary hypertension.2016
Author(s)
Chen J, Sysol JR, Shioura KM, Singla S, Yamamura H, Yamamura A, Reddy V, Torres J, Sridhar A, Tang H, Yuan JX, Garcia JG, Machado RF.
Organizer
AFMR Midwestern Regional Meeting
Place of Presentation
Chicago, USA
Related Report
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