The functional changes of Cav3.2 T-type Ca2+ channel and its regulatory factors in a mouse model for irritable bowel syndrome
Project/Area Number |
15K18882
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Pharmacology in pharmacy
|
Research Institution | Kindai University |
Principal Investigator |
Tsubota Maho 近畿大学, 薬学部, 講師 (90510123)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | Cav3.2 / 過敏性腸症候群 / 結腸過感受性 / T型カルシウムチャネル / 結腸痛 |
Outline of Final Research Achievements |
This study suggest that functional upreguation of Cav3.2 T-channel has occurred in the mice with butyrate-induced IBS, and thereby direct stimulation of TRPV1, indirect activation via PAR2 stimulation, and TRPA1 stimulation might contribute to colonic hyperalgesia. These findings demonstrate that an important suggestion for elucidating the molecular mechanism of the onset of IBS.
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Report
(4 results)
Research Products
(7 results)