| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
This study suggest that functional upreguation of Cav3.2 T-channel has occurred in the mice with butyrate-induced IBS, and thereby direct stimulation of TRPV1, indirect activation via PAR2 stimulation, and TRPA1 stimulation might contribute to colonic hyperalgesia. These findings demonstrate that an important suggestion for elucidating the molecular mechanism of the onset of IBS.
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