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Functional diversity and cardiac roles of purinergic P2Y6 receptor

Research Project

Project/Area Number 15K18883
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pharmacology in pharmacy
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

Nishimura Akiyuki  生理学研究所, 生体機能調節研究領域, 特任助教 (00457152)

Project Period (FY) 2015-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsGタンパク質共役型受容体 / シグナル伝達 / 心血管リモデリング / 細胞外ヌクレオチド / G蛋白質共役型受容体
Outline of Final Research Achievements

Cardiovascular remodeling which refers to the changes in size, structure and function of tissues, is important for homeostasis. However, excess remodeling leads irreversible dysfunction of tissues, resulting cardiovascular diseases. Here, we investigated the role of purinergic P2Y6 receptor (P2Y6R) on cardiovascular remodeling. In vascular system, angiotensin II (Ang II) functions as a physiological regulator of blood pressure, but it also play a major role in the pathological hypertension. P2Y6R forms heterodimer with Ang II type 1 receptor (AT1R). Developmentally increased P2Y6R-AT1R heterodimer promoted Ang II-induced hypertrophy of vascular smooth muscle cells and hypertension. These results suggest that increased formation of P2Y6R-AT1R heterodimer with age may increase the likelihood of hypertension.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report

Research Products

(17 results)

All 2017 2016 2015 Other

All Int'l Joint Research Journal Article Presentation Book

  • [Int'l Joint Research] Universiti Malaysia Sabah(Malaysia)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Universiti Malaysia Sabah(Malaysia)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] Universite Libre de Bruxelles(Belgium)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells.2017

    • Author(s)
      Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S, Akaike T.
    • Journal Title

      Free radical biology & medicine

      Volume: 印刷中 Pages: 132-140

    • DOI

      10.1016/j.freeradbiomed.2017.01.024

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Purinergic signaling in cardiovascular system2017

    • Author(s)
      Nishimura A, Nishida M.
    • Journal Title

      Folia Pharmacol. Jpn.

      Volume: 149 Issue: 2 Pages: 84-90

    • DOI

      10.1254/fpj.149.84

    • NAID

      130005306336

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Purinergic P2Y 6 receptors: A new therapeutic target of age-dependent hypertension2017

    • Author(s)
      Sunggip C, Nishimura A, Shimoda K, Numaga-Tomita T, Tsuda M, and Nishida M. M
    • Journal Title

      Pharmacol Res

      Volume: 120 Pages: 51-59

    • DOI

      10.1016/j.phrs.2017.03.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The purinergic P2Y6 receptor heterodimerizes with the angiotensin AT1 receptor to promote angiotensin II-induced hypertension.2017

    • Author(s)
      A. Nishimura, C. Sunggip, H. Tozaki-Saitoh, T. Shimauchi, T. Numaga-Tomita, K. Hirano, T. Ide, J-M. Boeynaems, H. Kurose, M. Tsuda, B. Robaye, K. Inoue and M. Nishida
    • Journal Title

      Sci Signal.

      Volume: Jan 19;9(411)

    • DOI

      10.1126/scisignal.aac9187

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling2016

    • Author(s)
      Kitajima N., Numaga-Tomita T., Watanabe M., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 37001-37001

    • DOI

      10.1038/srep37001

    • NAID

      120006323744

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis2016

    • Author(s)
      Numaga-Tomita T., Kitajima N., Kuroda T., Nishimura A., Miyano K., Yasuda S., Kuwahara K., Sato Y., Ide T., Birnbaumer L., Sumimoto H., Mori Y. and Nishida M.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 39383-39383

    • DOI

      10.1038/srep39383

    • NAID

      120005997825

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Light-dependent activation of G proteins by two isoforms of chicken melanopsins2015

    • Author(s)
      Masaki Torii, Daisuke Kojima, Akiyuki Nishimura Hiroshi Itoh, Yoshitaka Fukada
    • Journal Title

      Photochem Photobiol Sci

      Volume: 14 Pages: 1991-1997

    • DOI

      10.1039/c5pp00153f

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Divergent Roles of CAAX Motif-signaled Posttranslational Modifications in the Regulation and Subcellular Localization of Ral GTPases.2015

    • Author(s)
      LR Gentry, A. Nishimura, A.D. Cox, T.D. Martin, D. Tsygankov, M. Nishida, T.C. Elston and C.J. Der
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 290(37) Pages: 22851-22861

    • DOI

      10.1074/jbc.m115.656710

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Redox-dependent Regulation of H-Ras palmitoylation.2016

    • Author(s)
      Akiyuki Nishimura, Tomoya Ito, Takuro Numaga-Tomita, Motohiro Nishida
    • Organizer
      第9回国際NO学会 第16回日本NO学会
    • Place of Presentation
      宮城県、仙台市、仙台国際センター
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Developmentally upregulated P2Y6 receptor promotes angiotensin II-induced hypertensive signaling.2016

    • Author(s)
      Akiyuki Nishimura, Caloline Sunggip, Takuro Numaga-Tomita, Motohiro Nishida
    • Organizer
      International and Interdisciplinary Symposium 2016
    • Place of Presentation
      東京都、文京区、東京医科歯科大学
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 加齢に伴うAT1R-P2Y6R複合体形成によるアンジオテンシンII誘発性高血圧の制御2016

    • Author(s)
      西村明幸、Caroline Sunggip、冨田拓郎、西田基宏
    • Organizer
      第63回中部日本生理学会
    • Place of Presentation
      愛知県、岡崎市、岡崎コンファレンスセンター
    • Related Report
      2016 Annual Research Report
  • [Presentation] Drp1-細胞骨格の相互作用による心筋ミトコンドリアの品質管理2016

    • Author(s)
      西村明幸、島内司、石川達也、冨田拓郎、西田基宏
    • Organizer
      第26回日本循環薬理学会
    • Place of Presentation
      長野県、松本市、信州大学
    • Related Report
      2016 Annual Research Report
  • [Presentation] アンジオテンシンII誘発性高血圧に対するP2Y6受容体の役割2015

    • Author(s)
      西村明幸、Caroline Sunggip、冨田拓郎、西田基宏
    • Organizer
      第128回 日本薬理学会近畿部会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Year and Date
      2015-11-20
    • Related Report
      2015 Research-status Report
  • [Book] Japanese Scientists in Science Signaling 2016「シグナリングに載った日本人研究者」2017

    • Author(s)
      西村明幸、西田基宏
    • Total Pages
      2
    • Publisher
      米国科学振興協会
    • Related Report
      2016 Annual Research Report

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Published: 2015-04-16   Modified: 2018-03-22  

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