Establishing a new natural product ligand biosynthesis system for producing therapeutic agents for Alzheimer's disease
Project/Area Number |
15K18886
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Natural medicines
|
Research Institution | Iwate Medical University |
Principal Investigator |
ASANO TAKASHI 岩手医科大学, 薬学部, 助教 (10552888)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 毛状根 / 植物内生菌 / ヒガンバナアルカロイド / 植物共生 / アルカロイド生物合成 / LCMS-IT-TOF / 遺伝子発現変動解析 |
Outline of Final Research Achievements |
The cause of Alzheimer's disease is still unclear, so it cannot be completely cured. Most drug development is focused on delaying the progression of symptoms, and researchers have demonstrated the effectiveness of multiple alkaloids in this capacity. This study was focused on Amaryllidaceae and quinolizidine alkaloids. We established hairy root cultures that overexpresses quinolizidine alkaloid biosynthesis genes to provide a foundation for the production of effective therapeutic agents for Alzheimer's disease. We were also able to isolate alkaloid-producing endophyte from the bulb scales of a plant in the family Amaryllidaceae.
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Report
(4 results)
Research Products
(13 results)