| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The cause of Alzheimer's disease is still unclear, so it cannot be completely cured. Most drug development is focused on delaying the progression of symptoms, and researchers have demonstrated the effectiveness of multiple alkaloids in this capacity. This study was focused on Amaryllidaceae and quinolizidine alkaloids. We established hairy root cultures that overexpresses quinolizidine alkaloid biosynthesis genes to provide a foundation for the production of effective therapeutic agents for Alzheimer's disease. We were also able to isolate alkaloid-producing endophyte from the bulb scales of a plant in the family Amaryllidaceae.
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