Search for potential medicinal resources and construction of comprehensive information in Genus Dendrobium.
Project/Area Number |
15K18889
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Natural medicines
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Research Institution | Nihon University |
Principal Investigator |
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | ラン科セッコク属 / Dendrobium / 系統解析 / 代謝プロファイル / 薬用資源 / 多様性解析 / 薬用資源探索 / セッコク属植物 / 分類学 / 分子系統解析 / HPLCプロファイル / エキスの生理活性測定 / ラン科セッコク属植物 |
Outline of Final Research Achievements |
The genus Dendrobium, one of the largest genera in the Orchidaceae, includes 1100 species. Phylogenetic analyses based on morphological characteristics and DNA sequences indicated that the genus is divided into two major groups (Asian clade and Australasian clade). However, little is known about the chemical differences and similarities among the species in each clade. We selected 18 Dendrobium species and constructed HPLC profiles. Next, orthogonal partial least square discriminant analysis (OPLS-DA) was applied to the profile matrix to classify Dendrobium species into the Asian and Australasian clades in order to identify the peaks that significantly contribute to the class separation. In the results, two phenanthrenes, 4,9-dimethoxyphenanthrene-2,5-diol and 1,5-dimethoxyphenanthrene-2,7-diol, which contributed to the class separation, were isolated from the HPLC peaks. The existence of 1,5-dimethoxyphenanthrene-2,7-diol was limited to the genetically related Australasian species.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] Identification of two phenanthrene derivatives from Australasian allied species in genus Dendrobium.2018
Author(s)
Tomoko Takamiya, Saki Kitamura, Shunichiro Suzuki, Nao Shioda, Yoshifumi Matsuo, Kento Murase, Yuka Kaiho, Yurika Tsurumaki, Yukiko Fujiwara, Mayumi Sone, Tomomi Machida, Ryohei Matsumoto, Aoi Miyamoto, Dai Hirose, Megumi Furukawa, Mitsuko Makino, Keiichi Matsuzaki, Susumu Kitanaka, Tomohisa Yukawa, Hiroshi Iijima
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 66 No. 6
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] ラン科セッコク属植物エキスの抗炎症活性評価2016
Author(s)
高宮知子, 清水玲子, 菊地秦平, 吉野圭一, 町田智美, 曽根麻友美, 藤原有紀子, 松本亮平, 蒋文君, 北中進, 遊川知久, 飯島洋
Organizer
日本薬学会第136年会
Place of Presentation
パシフィコ横浜(神奈川・横浜)
Year and Date
2016-03-28
Related Report
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[Presentation] ラン科セッコク属植物エキスの微生物に対する影響の評価2016
Author(s)
菊地秦平, 清水玲子, 吉野圭一, 宮本智弘, 横山史歩, 蒋文君, 北中進, 鈴木和浩, 遊川知久, 飯島洋, 高宮知子
Organizer
日本植物園協会第51回大会
Place of Presentation
ウィング21(長野・白馬)
Related Report
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[Presentation] ラン科セッコク属の多様性解析に基づく薬用資源の探索2015
Author(s)
曽根麻友美, 藤原有紀子, 町田智美, 松本亮平, 菊地秦平, 清水玲子, 吉野圭一, 北中進, 遊川知久, 飯島洋, 高宮知子
Organizer
日本植物園協会50周年記念大会
Place of Presentation
国立京都国際会館(京都・京都)
Year and Date
2015-06-26
Related Report